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薬理と治療
Abstract
Objectives We previously reported the efficacy of citrus juice fermented with Lactiplantibacillus plantarum YIT 0132(LP0132)in the management of Japanese cedar pollinosis(JCPsis). This post hoc analysis evaluated symptoms and quality of life(QOL)in adults with mild JCPsis. Methods Participants from our previous study who had relatively mild JCPsis as defined by the Guideline on Notification of Foods with Function Claims were selected. Data of participants in the primary intention-to-treat analysis(n=50 per group)who met the guideline criteria were used in this post hoc analysis. Symptom scores, impaired QOL scores, and allergy-related blood parameters were compared to evaluate the efficacy of citrus juice fermented with LP0132. Results From the intention-to-treat analysis, data were selected for 44 participants in the LP0132 group and 49 in the placebo group who met the guideline criteria. The increase in symptom scores during the early part of pollen season was significantly suppressed in the LP0132 group compared with the placebo group. Impairment of QOL scores was also significantly suppressed in the LP0132 group compared with the placebo group and was positively correlated with total symptom score. A significant decrease in regulatory T cells was observed from enrollment to late March in the placebo group but not in the LP0132 group. These results were supported by propensity score matching analysis adjusted for medication score during the study period. Conclusions Citrus juice fermented with LP0132 alleviated JCPsis symptoms and impairment of QOL during the pollen season in participants with relatively mild JCPsis. (UMIN000025924)
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