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薬理と治療
Abstract
Objectives The constipation improving effect of jelly containing yuzu juice and β-glucan was evaluated in healthy subjects with a constipation tendency. Methods A jelly containing 5 g of yuzu juice and 20 mg of β-1,3-1,6-glucan per packet(18 g)was ingested for 3 months. Group 1 ingested one packet of jelly per day while group 2 ingested two packets of jelly per day. The Japanese version of the Constipation Assessment Scale(CAS)and the Bristol stool form scale(BSFS)of stool property score were used to evaluate the improvement of constipation. Doctorʼs diagnosis, blood pressure measurements, and blood tests were performed before, 1 month, and 3 months after the start of jelly intake. Results CAS score decreased significantly in both groups after 1 month and 3 months compared to the value before ingestion. In addition, BSFS significantly increased in the group with normal stool cases. However, one month after the end of ingestion, both CAS and BSFS tended to return to their values before ingestion. Furthermore, no problem was found in the results of doctorʼs diagnosis, blood pressure, and blood tests after 1 month and 3 months. Conclusions Jelly, which contains yuzu juice and β-glucan, was found to improve constipation, and the improvement was dependent on ingestion. In addition, results confirmed that there was no problem with safety during long-term ingestion. (UMIN-CTR ID:UMIN000027857)
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