薬理と治療

Abstract

Objectives　This randomized, double-blind, placebo-controlled, crossover study aimed to evaluate the effects of Kaempferia parviflora extract on body temperature. Methods　Twenty five healthy subjects were selected and assigned to two groups: the test food group and the placebo group. The test food group ingested the test food containing K. parviflora extract（0.49 mg╱day in the form of tetramethylluteolin）, while the placebo group ingested foods without any extract but with 100 mL water. Core body temperature was measured before ingestion and 10, 20, 30, 40, 50, and 60 min after ingestion. Body surface temperature was measured before ingestion and 30 and 60 min after ingestion. Results　The test food group showed a significant increase in core body temperature compared with the placebo group（P＜0.05）. The change in body surface temperature was not significant in the test food group as compared with the placebo group. During the study period, no adverse events attributable to the test foods were observed. Conclusions　These results suggest that ingestion of K. parviflora extract may be useful for maintaining body temperature. （UMIN-CTR ID: UMIN000045227）