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薬理と治療
Abstract
Objectives The purpose of this study was to investigate the effects of food consisting of rice bran fermented product containing 3-(4-hydroxy-3-methoxyphenyl)propionic acid(HMPA)on postprandial blood glucose control in healthy adults. Methods A randomized, double-blind, placebo-controlled, parallel-group study was conducted in 30 healthy volunteers with elevated postprandial blood glucose. Volunteers were randomly assigned to receive either test food or placebo. Daily intake of the test food for 4 weeks. After 4 weeks, volunteers performed a glucose tolerance test without the test food ingestion and evaluated changes in postprandial blood glucose levels. Results All 30 volunteers completed this study. In the test food group, blood glucose levels 2 hours after the glucose tolerance test were significantly lower than in the placebo food group(P<0.05). Moreover, maximum concentration time(Tmax)of blood glucose in the glucose tolerance test was smaller in the test food group than the placebo group. During the study period, no adverse events attributable to the test food were observed. Conclusion The study revealed that the consumption of the food containing rice bran ferment lowers postprandial elevated blood glucose levels by improving glucose metabolism, rather than by inhibiting glucose absorption in healthy adults.(UMIN-CTR ID: UMIN000044481)(Jpn Pharmacol Ther 2022;50:791‒9)
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