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完熟オクラ種子抽出物の肌弾力に及ぼす影響―ランダム化二重盲検プラセボ対照比較試験―
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JPY
Abstract
Objective We found that mature okra seeds extract had an inhibitory effect on fibroblast-derived elastase activity. In this study, we examined the effect of mature okra seeds extract on improving skin elasticity in a clinical study. Methods A randomized, placebo controlled, double-blind, paralleled study was conducted for 23 healthy subjects(11 males and 12 females aged from 30 to 65 years). Subjects consumed either placebo or test food(300 mg╱kg of mature okra seeds extract, containing OF4949-Ⅱ)for 12 weeks. The elasticity of the skin was measured with a Cutometer® DUAL MPA, and the parameters of R2, R5, and R7 were evaluated. Results Ingestion of mature okra seeds extract significantly improved R2 and R7 values compared to the placebo group. Conclusion These results suggest that mature okra seeds extract, which inhibits fibroblast-derived elastase activity, improves skin elasticity in healthy subjects. (Jpn Pharmacol Ther 2022;50:835‒41)
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