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薬理と治療
Abstract
Background and purpose Natto was made from soybeans fermented with Bacillus subtilis (natto)and B. subtilis(natto)ware present on the surface of natto. Natto and B. subtilis(natto) were known as probiotics, but the immunostimulatory function was not well known. We examined the immunostimulatory effect of B. subtilis(natto)and natto epidermis. Methods We measured the IFN-γ production levels of mouse spleen cells stimulated with B. subtilis(natto)and natto epidermis in vitro. Mice were orally administered with Natto epidermis for 7 days and the spleen cells were collected and used for the measurement of NK activity and IFN-γ production. Results IFN-γ production from mouse spleen cells significantly increased after stimulation with B. subtilis(natto). This effect was stronger in the vegetative cell than in the spore. Although there was no immunostimulatory effect on boiled beans, natto and natto epidermis induced IFN-γ production, and natto epidermis was more effective. The NK activity in mice administered with natto epidermis was higher than that in control mice. Conclusion These results indicated that B. subtilis(natto)and natto epidermis exert immunostimulatory effects, especially activation of innate immunity. (Jpn Pharmacol Ther 2022;50:1195‒9)
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