薬理と治療

Abstract

Objectives　The objective of this study was to evaluate the effect of long-term consumption of green tea beverage containing quercetin glucosides in combination with walking exercise on body fat accumulation in obese subjects. Methods　A randomized, placebo-controlled, double blind intervention trial was conducted on 148 subjects with 25≦body mass index（BMI）＜30. They were divided into two groups and ingested either active beverage containing 110 mg quercetin glucosides（as isoquercitrin）or placebo beverage for 12 weeks. All participants were instructed to walk about 3000 steps╱day than they had before the trial. Results　A 12 weeks combination of walking exercise and consumption of a green tea beverages containing quercetin glycosides significantly reduced total area of abdominal fat. Conclusions　This study proved that a combination of taking 500 mL of green tea beverages containing 110 mg quercetin glucosides（as isoquercitrin）per day and walking exercise involving an additional about 3000 steps per day for 12 weeks reduces body fat for obese men and women（25≦BMI＜30）（Jpn Pharmacol Ther 2022；50：1229‒38）