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Impacts of salmon nasal cartilage—derived proteoglycans on maintaining muscle mass in healthy subjects―A randomized, placebo—controlled, double—blind, parallel—group comparison study―
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JPY
Abstract
Inflammation linked to age or physical inactivity has been recognized as a major factor in muscle mass decline. This randomized, placebo–controlled, double–blind, and parallel–group comparison study sought to determine the effects of consuming salmon nasal cartilage–derived proteoglycan complex(SNC–PGs)with anti–inflammatory effects on muscle mass in healthy Japanese adults who felt a muscle strength decline. Fifty–six subjects were randomly designated to the SNC–PGs group(n=28)or the placebo group(n=28)and consumed each test product(SNC–PGs 40 mg/day)for 24 weeks. Body composition was measured 12 and 24 weeks after the intervention. Furthermore, the test foodʼs safety was evaluated. The efficacy analysis dataset as per the protocol set(PPS)comprised 24 subjects per group. The SNC–PGs group had significantly higher muscle mass than the placebo group at 12 and 24 weeks. Safety assessment indicated no medically significant changes because of the continued consumption of the test food. Conclusively, SNC–PGs consumption for 24 weeks enhanced the maintenance of muscle mass in healthy Japanese adults who noticed a muscle strength decline (UMIN000042714).(Jpn Pharmacol Ther 2023;51:711‒47)
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