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Journal of Mammalian Ova Research
- Authors: Fumihiro Kojima1, Shunsaku Fujii1, Rie Fukuhara1, Rika Nakamura1, Hidetaka Kimura1, Eiji Yamaguchi2, Atsushi Fukui1, Hideki Mizunuma1
Abstract
ABSTRACT
The relationship between morphologic criteria including zona pellucida thickness (ZPT) and the ET outcomes was studied for day-4 fresh morula transfer (n=306). Pregnancy rate (PR) was significantly correlated with the proportion of compaction (P<0.0001), the morphology (P<0.0001) and the amount of fragmentation (P=0.0004) of the best morula. In cycles with single morula transfer (n=121), only the morphology was significantly correlated with PR (P=0.03). The average ZPT of the best morula was significantly thinner (P<0.0001) in conception cycles (7.9 ± 2.1 μm) than in non-conception cycles (9.3 ± 1.8 μm). Also in cycles with single morula transfer, the average ZPT was significantly thinner (P=0.004) in conception cycles (8.5 ± 1.9 μm) than in non-conception cycles (9.7 ± 2.0 μm). Factors influencing conception were assessed by logistic-regression analysis. The average ZPT (P<0.0001), the morphology (P=0.0003) and the amount of fragmentation (P=0.02) of the best morula were significantly related to the conception, whereas only the average ZPT (P=0.01) was related to the conception in single morula transfer cycles. We concluded that the average ZPT and the morphology of embryo seem to be strong predictors of pregnancy in day-4 morula transfer and thus important indicators of good embryo quality.
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