Therapeutic Research
Volume 30, Issue 4, 2009
Volumes & issues:
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OPINION
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Symposium
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- 第3回循環器病学の論点−controversy in cardiology−
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- GERD研究会第13回学術集会
- Session I
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- Session II
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- Session III
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Review
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原著
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Anti?inflammatory and cholesterol lowering effects of fluvastatin with dose increasing from 20 mg to 30 mg
30巻4号(2009);View Description Hide DescriptionIt is considered that the disorder of cholesterol metabolism and an inflammatory response are associated with cardiovascular risk. In order to prevent cardiovascular disease, a strict control of cholesterol level and suppression of inflammatory response should be needed. The aim of this study is to evaluate the risk reducing effects of fluvastatin at increasing daily dose from 20 mg to 30 mg in patients with dyslipidemia. During the treatment with fluvastatin 20 mg and 6 months after the treatment with fluvastatin 30 mg, lipid profiles, high−sensitive CRP(hs−CRP)as a inflammatory parameter and ankle−brachial PWV (baPWV)were measured. In 37 patients, LDL cholesterol and hs−CRP were significantly decreased from 134±33 mg/dL to 116±29 mg/dL(p<0.001)and from 0.086±0.066 mg/dL to 0.071±0.048 mg/dL(p=0.016), respectively. The baPWV was also decreased from 1743±384 cm/sec to 1659±335 cm/sec(p<0.016). Changes in blood pressure and heart rate were not significantly. The dose increasing treatment with fluvastatin 20 mg to 30 mg may be more potent on cholesterol lowering and anti−inflammatory effects for patients with dyslipidemia. -
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疼痛を伴う原発性骨粗鬆症に対するエルカトニン長期治療による検討
30巻4号(2009);View Description Hide Description骨粗鬆症の治療は長期にわたることから,薬剤評価も長期にわたる有効性および安全性が検証されなければならない。今回,わが国において 20 年以上にわたって骨粗鬆症治療に用いられているエルカトニンについて,5 年以上の長期投与を施した患者における有効性と安全性を後ろ向きに検討した。対象症例は当院に通院された骨粗鬆症患者30 例で 1 例を除き,腰背部痛を訴えていた。エルカトニンは 20 単位を週 1 回,12 週間投与し,その後 3 ヵ月間休薬期間をおき,これを 1 クールとして繰り返し行った。なお活性型ビタミンD3 0.5μg/日は原則継続とした。その結果,エルカトニン初回 12 週間投与後の疼痛は有意に改善し,疼痛の消失率は 93.1%であった。また,エルカトニンを投与した計381 クールの開始時の疼痛も,投与クール終了時点では有意に改善し,疼痛消失率は 63.2%であった。橈骨骨密度はエルカトニン投与により,12 年間にわたって同年齢標準値の変化と比較して高値を維持した。今回,ビタミン D3併用による,エルカトニンの長期間の断続投与により鎮痛効果と骨密度減少抑制効果が確認された。エルカトニンは骨粗鬆症の日常外来診療において疼痛改善および骨密度の維持効果の二つの効果を長期にわたり期待できる薬剤であることが示唆された。 -
Comparison of blood flow velocity in the middle cerebral artery between men and women at rest and during exercise
30巻4号(2009);View Description Hide DescriptionThe differences in the middle cerebral artery blood flow velocity(MCA_V)and systemic arterial blood pressure(BP)between 10 healthy young males and 10 healthy young females were examined at rest and during 6 min of cycle exercise at an intensity of 100W for males and 50W for females. The systolic, diastolic, and mean MCA_V were continuously measured using a transcranial Doppler ultrasound velocimeter. The systolic, diastolic, and mean BP were also recorded by sphygmomanometry. The mean MCA_V(MCA_Vm)for both males and females was significantly(each p<0.05)increased by 18.7% and 17.3%, respectively, from rest to exercise. The mean values of MCA_Vm at rest and during exercise for females were significantly(p<0.05)greater than the corresponding values for males(rest 63.5±14.7 vs. 48.6±11.6 cm sec−1, exercise 72.8±11.7 vs. 57.5±14.6 cm sec−1). In contrast, the mean BP(MBP)was significantly(p<0.05)less in females than in males during exercise, whereas the MBP at rest was not significantly different between the two groups. Furthermore, to clarify the females’ greater MCA_Vm in terms of physiological significance, we simulated the volumetric blood flow through the MCA and its potential for oxygen delivery to the downstream tissues by applying the physiological data available from the literature and from the experiments. The greater blood flow in the MCA in females compensates for the relatively lower arterial oxygen content, which is transported as oxyhemoglobin contained in a smaller number of red blood cells, to give a similar oxygen transport to that in males. These results suggest that the females’ greater MCA_Vm, compensating for the lower arterial oxygen content, plays an important role in efficiently transporting oxygen through the bloodstream to tissues at a similar level to that of males.
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