Therapeutic Research
Volume 30, Issue 8, 2009
Volumes & issues:
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Symposium
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- 第73回日本循環器学会総会
- 学術集会ランチョンセミナー
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心不全の治療オプションとしての陽圧呼吸療法?Adaptive servo ventilation(ASV)の有用性を中心に?
30巻8号(2009);View Description Hide Description - 第73回日本循環器学会総会・学術集会ファイアサイドセミナー
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- 第7回DPB・難治性気道疾患研究会
- 一般演題I
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- 一般演題II
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- 特別発言
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- 特別シンポジウム:DPBについてわかったこと,わかっていないこと
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Review
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エビデンスに基づいたCOPD薬物治療のすすめかた
30巻8号(2009);View Description Hide Description近年,UPLIFT,TORCH などの大規模臨床試験が報告され,COPD における薬物治療のエビデンスが蓄積されてきた。一方,サルメテロール/フルチカゾン配合剤(SFC)の COPD での適応追加にみられるように,使用する薬剤の選択肢も広がってきた。そこで,COPD の病態生理や薬物治療のエビデンスをあらためて示し,ガイドラインに基づく適切な薬物治療戦略について解説する。
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原著
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ストロングスタチンの非連日投与による有効性,安全性および相互関係について?アトルバスタチン,ピタバスタチン,ロスバスタチンにおける検討?
30巻8号(2009);View Description Hide Description -
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Functional Dyspepsia(FD)患者とNon?erosive Gastroesophageal Reflux Disease(NERD)患者との胃内送気刺激下胃内圧測定の反応性の特徴
30巻8号(2009);View Description Hide Description -
Additional Effects of Pranlukast on Exhaled Nitric Oxide Levels in Patients with Persistent Asthma
30巻8号(2009);View Description Hide DescriptionBackground:Leukotriene receptor antagonist(LTRA)and/or long−acting beta2−agonist(LABA)agents are considered as add−on therapy to inhaled corticosteroids(ICS).We aimed to assess the additional effects of pranlukast to combination therapy with ICS and LABA on exhaled nitric oxide(NO)levels in patients with persistent asthma.Methods:Twenty outpatients with mild to severe persistent asthma, who were managed with combination therapy with ICS and inhaled LABA(salmeterol 100μg/day),were given pranlukast(450 mg/day)for 4 weeks as add−on therapy. Exhaled NO measurements and spirometry tests were performed at entry, after add−on therapy period, and after wash−out period.Results:Exhaled NO levels decreased significantly after add−on treatment period [26.6(1.1)ppb at entry, 18.3(1.9)ppb at the end of add−on period, and 21.1(1.1)ppb at the end of wash−out period;geometric means(GSEM)]. FEV1 increased significantly after add−on treatment period[2.08±0.12 L at entry, 2.14±0.56 L on add−on therapy, and 2.08±0.58 L at the end of wash−out period;means±SEM].Conclusion:Our findings indicate that pranlukast inhibits eosinophilic airway inflammation that remains in patients with persistent asthma given combination therapy with ICS and inhaled LABA. -
Effects of Doxapram on Myocardial Repolarization in Anesthetized Rats
30巻8号(2009);View Description Hide DescriptionThe inhibitory effects of doxapram, a respiratory accelerator, on the cardiac impulseconducting system and myocardial repolarization time were investigated in anesthetized animals using electrocardiography.Doxapram prolonged QT and QTcF, which are indicative of the myocardial repolarization time, in a dose−dependent manner in rats anesthetized by sevoflurane. However,prolongation of the atrioventricular conduction time was not observed, even at the maximum dose(10 mg/kg), and deterioration of either the QT variability index or QT variability ratio,indices of time−dependent variation in cardiac cycle and myocardial repolarization, was not observed. Doxapram prolonged the myocardial repolarization time at high doses, but maintained the physiologically valid QT/RR relationship and did not increase proarrhythmia.
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