Therapeutic Research
Volume 35, Issue 8, 2014
Volumes & issues:
-
Symposium:第78回日本循環器学会学術集会ランチョンセミナー
-
-
-
Symposium:第41回関西高血圧研究会
-
- 一般演題
-
-
-
頻回座位血圧測定における拡張期血圧の変動
35巻8号(2014);View Description Hide DescriptionBlood pressure levels in clinical office tend to be variable. Therefore 2 times measurements of blood pressure with interval of 1 –2 minutes have been advocated by guidelines (JSH 2014). Furthermore we have tried 5 times measurements with 1 minute interval for obtaining reliable blood pressure of upper arms in clinical office using oscillometric method (HEM 8723, Omron). In this study 193 outpatients(99 males, 94 females) aged 18 –90 were recruited. By first diastolic blood pressure levels 4 groups were divided: 60–69 mmHg (21males, 22 females), 70–79(27, 23), 80–89(22, 22), 90–99(21,17), who accepted any antihypertensive drugs in 36.8% of males and 33% of females. Outpatients without drug( 8 males, 10 females) were also examined, who showed 90 –99 mmHg of first diastolic blood pressure. From these 2 observations 5th measurement tended to show greater lowering of diastolic blood pressure levels as compared with 2nd –3rd ones, especially in females. Then the differences between home blood pressure(early morning) and office blood pressure levels of the same day were small in males but great in females, showing higher levels of female office blood pressures than male ones. -
-
原著
-
-
頭頸部悪性腫瘍の放射線治療に伴う口腔乾燥症状に対するピロカルピン塩酸塩の安全性および有効性の検討-使用成績調査-
35巻8号(2014);View Description Hide DescriptionObjective:This use –results survey was conducted under the actual status of theusage to evaluate the safety and efficacy of pilocarpine hydrochloride(Salagen® tablets) in patients with xerostomia induced by radiotherapy for head and neck cancer. Methods:Of the specialized medical institutions equipped with radiotherapy equipment, eligible ones participated in this specific –institution all –case surveillance. The patients were observed for 12 weeks, and for those with continuous treatment, data were collected until week 52. Results:Of the 2155 patients evaluated for safety, 31.79%(685 patients, 849 episodes)experienced adverse drug reactions(ADRs). The main ADRs included 466 episodes of hyperhidrosis, 39 of nausea, 28 of diarrhea, 24 of pollakiuria, and 22 of abdominal discomfort. Serious ADRs were encountered by 11 patients(14 episodes). The incidence of cardiovascular system ADRs, one of the priority survey items, was 1.76%(38 patients, 42 episodes). No marked increase in the incidence of ADRs occurred with the increase in the duration of administration. The efficacy rates at 12 weeks and final evaluation in the 1983 patients evaluated for efficacy were 56.2 and 53.4%, respectively, showing that improvement was noted in more than half of the patients surveyed. Conclusions:Long–term treatment with pilocarpine hydrochloride was confirmed to be safe and effective in this use –results survey in patients with xerostomia induced by radiotherapy for head and neck cancer. -
リラグルチドのBody Mass Index(BMI)別臨床効果に関する解析―前治療別による比較検討―
35巻8号(2014);View Description Hide DescriptionGLP–1 analogue, liraglutide, improves glycemic control by stimulating endogenousinsulin secretion in a glucose–dependent manner, and inhibiting excessive caloric intake in type 2 diabetic(T2DM)patients. We retrospectively evaluated efficacy of liraglutide associated with body mass index(BMI)in Japanese T2DM patients treated with liraglutide over 12 weeks. The average of total daily dose of insulin was 11.8±5.4U/day before switching to liraglutide. The average regimen of insulin injection was 2.4±1.2 times/day. Liraglutide in the patients with no previous treatment or treated with oral hypoglycemic agents showed greater efficacy on glycemic control estimated by HbA1c(NGSP)than that in patients switching from insulin, but not on body weight reduction. BMI did not affect efficacy of liraglutide on body weight reduction and glycemic control in the patients with no previous treatment or treated with oral hypoglycemic agents. In contrast, body weight reduction by liraglutide was significantly higher in the obese patients(30kg/m2 ≦BMI)switching from insulin than the patients with normal BMI. We demonstrated efficacy of liraglutide on glycemic control and body weight reduction and the association with BMI in Japanese T2DM patients. -
間質性肺炎治療中のステロイド性骨粗鬆症対策におけるエルデカルシトールの効果
35巻8号(2014);View Description Hide Description背景:ステロイドは間質性肺炎治療において重要な薬剤であるが,その投与は長期化することが多く副作用対策を軽視することはできない。ステロイドによるさまざまな有害事象のなかで,ステロイド性骨粗鬆症も重要であるが,間質性肺炎の治療領域におけるその対策は十分とはいえないのが現状である。対象と方法:間質性肺炎に対するステロイドとステロイド性骨粗鬆症対策としてのビスホスホネート(BP)製剤を長期にわたり使用し,エルデカルシトール(ELD)を上乗せした10 例の患者を対象とした。ELD上乗せ時,およびその6 ヵ月後の骨密度と骨代謝マーカー測定値をカルテベースで調査し検討を行った。結果:観察期間内において新規の骨関連イベントはなく,ELD追加6 ヵ月後には骨密度は増加し,骨吸収マーカーである酒石酸抵抗性酸ホスファターゼ–5bが減少した。また,血清カルシウムの上昇などもみられなかった。結論:間質性肺炎に対するステロイド治療においても,骨粗鬆症対策としてのBP製剤に対するELDの上乗せ効果の可能性が示唆された。 -
経皮吸収型鎮痛・抗炎症貼付剤の使用感に関するアンケート調査
35巻8号(2014);View Description Hide DescriptionAdhesive tape type antiphlogistic sedative patches(ATTASP) have been frequently used among orthopedists in daily medical treatment. However, in spite of promotion, there seems to be some hesitation in using generic drugs due to the difference of usability. Accordingly, conversion from the original patches to the generic drugs is not positively done. We, therefore, carried out questionnaire survey to investigate usability, easiness to put on, and duration of effect about ATTASP. We now clarified factors that had an influence on them. As a result, it is desirable that ATTASP should be prescribed after enough understanding of the disease condition and explanation to the patients.
-