Volume 39,
Issue 10,
2018
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Series:呼吸ケア・フロントランナー
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Source:
Therapeutic Research 39巻10号, 843-846 (2018);
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原著
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Source:
Therapeutic Research 39巻10号, 879-890 (2018);
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Background/Purpose:In this study, we compared and examined the characteristics and anesthetic effect of ① Lidocaine/Propitocaine(EMLA®, abbreviated as L/P cream) and ② 2L cream(7% lidocaine), ③ PL cream(3.5% lidocaine+2.5% procaine), ④ 2PL cream(7% lidocaine+5% procaine), ⑤ 2 P+L cream(3.5% lidocaine+5% procaine) which were the in‒hospital formulations. Methods:Various creams were stored in an ointment container, and the residual rate of the component amount after 21879 days was measured by HPLC method. For the quantitative evaluation of the anesthetic effect, after applying various creams to the inside of the forearm, the degree of pain was measured with time using Pain Vision. Results:L/P cream was significantly higher in moisture evaporation rate than other creams and had low spreadability. Regarding viscosity and hardness, 2P+L cream was the lowest value and 2PL cream was the highest value. In the stability test at 4℃ after 21 days, residual rate of L/P cream was amounted to 80% or more and all four creams were amounted to 70% or more. As for the anesthetic effect after wiping 90 minutes after application, 2L cream and 2PL cream had no significant difference compared with 30 minutes after the lapse, suggesting sustained anesthetic effect. Discussion:In this study, it was shown that there was a relationship between the lidocaine concentration and the longevity of the anesthetic effect. More improvement of the in‒hospital formulations will be required, as it will be important to select the optimal formulation according to the clinical need.