Volume 36,
Issue 10,
2008
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TOPICS
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日本メディカルライター協会(JMCA)第6回ヘルスコミュニケーション・シンポジウム
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Source:
薬理と治療 36巻10号, 877-877 (2008);
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食品・医薬品に関するエビデンスは正しく伝えられているか?-事例に見る問題点と留意点-
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Source:
薬理と治療 36巻10号, 878-878 (2008);
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薬理と治療 36巻10号, 879-880 (2008);
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薬理と治療 36巻10号, 881-882 (2008);
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Source:
薬理と治療 36巻10号, 883-884 (2008);
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薬理と治療 36巻10号, 885-886 (2008);
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薬理と治療 36巻10号, 887-888 (2008);
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ORIGINAL ARTICLES
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薬理と治療 36巻10号, 893-898 (2008);
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We investigated the characteristics of sodium hypo−chloride with acetic acid supplementation(A−NaOCl). Bactericidal effect was superior on A−NaOCl than sodium hypo−chloride (NaOCl). Bactericidal effect was remarkably decreased by organic matter contamination on A−NaOCl. Oxidation of metal and production of chloride gas or hypo−chloride ion was less caused by A−NaOCl than NaOCl. From these results, we conclude that A−NaOCl useful could bactericidal agent in clinical setting.(Jpn Pharmacol Ther 2008;36:893−8)KEY WORDS Weakly acidic solution, Sodium hypo−chloride with acetic acid supplementation
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薬理と治療 36巻10号, 899-907 (2008);
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Zinc is an essential trace element in the living body and is closely related to healing of injuries, dermal stabilization, activation of hormones, stabilization of the mind and nerves, retention of immunocompetence, etc. The serum zinc levels of rheumatoid arthritis patients are low, which may be associated with a decrease in QOL. Thus, the serum zinc levels of 312 patients with rheumatoid arthritis were determined. Polaprezinc, a drug containing zinc to cure gastric ulcer(Zn 34 mg/day), was administered to 228 cases(73.1%)whose serum zinc levels were lower than 70μg/dL. Of these, 81 cases who were medicated with polaprezinc for more than 6 months and who were taking the same drugs for the treatment of rheumatoid arthritis as before were studied to examine the variation of serum zinc level, presence or absence of improvements in subjective symptoms, and DAS28. Of the 81 cases, a rise in serum zinc level was noted in 64 cases(79.0%), and in these cases the CRP level and DAS28 were significantly improved. Subjective symptoms in mental instability and dysgeusia were improved. In addition, 17 cases with no change in serum zinc level nevertheless showed improvement in subjective symptoms such as arthralgia, articular distention, fatigue, rough skin, and stomatitis. The subjective symptoms of 19 cases who could not be treated with polaprezinc even though their serum zinc levels were low did not improve at all and their DAS28 also did not improve. As a result, it is suggested that the replenishment of zinc for rheumatoid arthritis patients may improve QOL.(Jpn Pharmacol Ther 2008;36:899−907)KEY WORDS DAS28, Polaprezinc, Rheumatoid arthritis, Zinc
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Source:
薬理と治療 36巻10号, 911-918 (2008);
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Objectives Chicken collagen hydrolysate(Chicken−Collagen Octa Peptides;C−COP)contains a peptide with angiotensin converting enzyme(ACE)−inhibitory activity. 12 weeks of CCOP administration at 2.9 g/day has already been found to reduce blood pressure in humans. Here, we sub−analyzed the efficacy of C−COP to the subjects with high−normal blood pressure. Methods Blood pressure were analyzed during 2 observational weeks before treatment of 120 subjects with mild hypertension. 80 subjects who recorded below the high−normal blood pressure in this period were chosen as the study subjects with high−normal blood pressure. These subjects were randomly grouped into a test−food group(41)which was given a lactic acid bacteria drink containing C−COP at 2.9 g/day, and a placebo control group(39). The clinical trial designed a double−blind, placebo−controlled to investigate the hypotensive action of C−COP. Results In the test−food group, systolic blood pressure was significantly reduced compared with the placebo group at 8 and 12 weeks after the intake of the test−food(p<0.05). When compared with the baseline values, a reduction in blood pressure was found at 2, 10 and 12 weeks in the test−food group(p<0.01, p<0.1 and p<0.1, respectively). Furthermore, a significant reduction of diastolic blood pressure in the test−food group was confirmed 12 weeks after treatment compared with the control group(p<0.05). Conclusions These results suggest that the lactic acid bacteria beverage containing CCOP is useful for reducing blood pressure of a person with high−normal blood pressure.(Jpn Pharmacol Ther 2008;36:911−8)KEY WORDS C−COP(Chicken−Collagen Octa Peptides), ACE−inhibitory activity, Subgroup analysis, High−normal blood pressure
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Source:
薬理と治療 36巻10号, 919-930 (2008);
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Objectives The objective of this study was to investigate effect of the long−term intake of polyphenols derived from Japanese pagoda tree(enzymatically modified isoquercitrin)on body fat accumulation in overweight and obese subjects. Methods 【The 1st study】A single−blind placebo−controlled cross over study was conducted on 21 subjects(16 men and 5 women)to evaluate energy metabolism during exercise. 【The 2nd study】A double−blind placebo−controlled study was conducted on 200 overweight and obese subjects(102 men and 98 women)to evaluate body fat accumulation. They were randomly divided into two groups and ingested the beverage containing 0 mg or 275 mg of polyphenols for 12 weeks. Results 【The 1st study】Fat oxidation increased significantly during exercise in test group compared to placebo group.【The 2nd study】Abdominal total fat area, visceral fat area, subcutaneous fat area and waist circumference reduced significantly in test group compared to placebo group. No adverse events related to the bevelages were obserbed in both groups. Conclusions These results suggest that the long−term intake of polyphenols derived from Japanese pagoda tree reduced body fat safely, and might be useful for prevention and improvement of obesity and metabolic syndrome.(Jpn Pharmacol Ther 2008;36:919−30)KEY WORDS Japanese pagoda tree polyphenols, Quercetin glucoside, Fat oxidation, Body fat, Metabolic syndrome
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Source:
薬理と治療 36巻10号, 931-939 (2008);
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Objective A double−blind placebo−controlled study for 4 weeks was conducted on 48 subjects to evaluate the safety of the drink containing Japanese pagoda tree polyphenol (enzymatically modified isoquercitrin)in the case of excessive intake in healthy adults include obesity persons. Methods Healthy adults include obesity persons(male=24, female=24, mean 36.6±10.0 years old, mean 24.8±2.9 BMI)were randomly divided into two groups, one is test group and the other is placebo group. The test group ingested daily 3 bottles of test drink(350 mL/bottle, total 1050 mL), which is equal to three times as much as regular amount of recommended daily intake of the drink, for 4 weeks. On the other hand, the placebo group ingested the same amount of placebo drink for the same duration. Results Statistically significant decrease in body weight and BMI after 4 and 6 weeks of feeding in the test group were observed, but these were not thought to be no clinically concerning changes. Changes in the body fat percentage, waist size, vital sign, blood parameters and urine parameters were not observed during intake period. No adverse event attributed to the test drink was found in the study. Conclusions Thus, these results indicated the safety of the drink containing Japanese pagoda tree polyphenol in healthy adults include obesity persons in the case of excessive intake.(Jpn Pharmacol Ther 2008;36:931−9)KEY WORDS Japanese pagoda tree polyphenol (enzymatically modified isoquercitrin), Safety, Excessive intake
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Source:
薬理と治療 36巻10号, 941-950 (2008);
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Objectives We developed a coffee beverage supplemented with indigestible dextrin. In this study, we investigated whether the beverage suppressed the postprandial elevation of blood glucose level of healthy volunteers. We also evaluated the safety of the beverage. Methods Human trial 1. We carried out a double−blinded crossover trial. 42 volunteers (45.0±12.7 years old)ingested a test meal with a 280 mL−bottle of the coffee beverage supplemented with 5 g of indigestible dextrin or a placebo. The blood glucose level and insulin level were measured after meal. Human trial 2. We carried out 2 open−label trials to evaluate the safety of the beverage. In the first trial, 14 volunteers(42.3±15.0 years old), including 2 volunteers with impaired glucose regulation(110≦FGP<126), consumed the coffee beverage 3 times a day for 12 weeks. In the second trial, 15 volunteers(45.2±13.9 years old), including 3 volunteers with impaired glucose regulation, consumed another coffee beverage supplemented with an excessive amount of indigestible dextrin 3 times a day for 4 weeks. They had health interviews, blood and urine tests during the test periods. Results Human trial 1. Concurrent ingestion of the coffee beverage with the test meal significantly lowered the blood glucose level at 30 minutes after meal compared to that after concurrent ingestion of the placebo. Although the coffee beverage did not affect the blood insulin level significantly, it reduced the area under the blood insulin concentration−time curve until 120 minutes after meal significantly. Human trial 2. No harmful effect of the coffee beverages was observed throughout the study periods. Conclusions The data suggested that the coffee beverage supplemented with indigestible dextrin suppresses the elevation of the postprandial blood glucose level and that the bever age is safe when it is consumed continuously at the recommended dose. (Jpn Pharmacol Ther 2008;36:941−50)KEY WORDS Indigestible dextrin, Coffee, Blood glucose level, Safety
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CASE STUDY
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Source:
薬理と治療 36巻10号, 953-956 (2008);
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We are presenting here, a patient of severe and obstinate essential tremor successfully treated with taltirelin hydrate, that is a thyrotropin−releasing hormone(TRH)analogue and used for the treatment of spinocerebellar ataxias in Japan.(Jpn Pharmacol Ther 2008;36:953−6)KEY WORDS Essential tremor, Taltirelin, Thyrotropin−releasing hormone analogue