Volume 39,
Issue 10,
2011
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扉・目次
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Source:
薬理と治療 39巻10号, 841-843 (2011);
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TOPICS
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第10回CRCと臨床試験のあり方を考える会議 2010 in別府
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Source:
薬理と治療 39巻10号, 846-846 (2011);
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薬理と治療 39巻10号, 847-848 (2011);
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薬理と治療 39巻10号, 849-850 (2011);
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薬理と治療 39巻10号, 851-852 (2011);
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薬理と治療 39巻10号, 853-854 (2011);
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DRUG PROFILE SERIES
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薬理と治療 39巻10号, 857-875 (2011);
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ORIGINAL ARTICLES
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薬理と治療 39巻10号, 879-887 (2011);
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The aim of this study was to investigate the effect of ethylenediurea(EDU:N-[2-(2-oxo-1-imidazolidinyl)ethyl]-N-phenylurea)which induced superoxide dismutase(SOD)and catalase(CAT)activities, on linoleic acid hydroperoxide(LHP)-induced PC12 cell injury.PC12 cells were cultured in RPMI 1640 medium with antibiotics. PC12 cell viability wasdetermined by crystal violet(CV)stain 24 hr after 0.05 mM LHP addition. At 6 hr after 0.05mM LHP addition, single-stranded DNA(ssDNA)was determined by ssDNA ApoptosisELISA kit. Caspase-3, SOD-1 and CAT mRNA were determined by Quantitative Real Time-PCR. After LHP addition, PC12 cell viability was significantly decreased to 70% of control(without treatment, p<0.01). The addition of 0.1 mM EDU 1 hr before LHP addition, PC12cell viability returned to 93%. Apoptosis was significantly increased by LHP treatment(447%, p<0.01)and it was significantly decreased to 248% by EDU treatment(p<0.01).Caspase-3 mRNA was increased by LHP treatment(170%), and it was decreased by EDUtreatment(145%). SOD-1 mRNA was increased by LHP, EDU and both treatments:119%,132% and 107% of control, respectively. CAT mRNA was not increased. These results indicatethat EDU exerts a protective effect against LHP-induced PC12 cell injury in partthrough an inhibition of apoptosis.
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Source:
薬理と治療 39巻10号, 889-900 (2011);
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Objective “KURO-Oolong tea OTPP”is a FOSHU(Food for specified health uses)tea,which inhibits fat absorption, and suppress postprandial triglyceride level. To elucidate potentialof“KURO-Oolong tea OTPP”to reduce risk for metabolic syndrome, we investigatedeffects of the long-term intake of“KURO-Oolong tea OTPP”on body fat mass.Methods We performed a randomized double-blind, placebo-contorolled trial. The subjects(166 men and 134 women)aged from 20 to 65 years old with 25.0≦body mass index(BMI)<30.0 kg/m2 were randomly divided into two groups;“KURO-Oolong tea OTPP”(OTPP 70mg/350 mL)group, and placebo group. Each subject consumed one bottle with a meal twice aday for 16 weeks.Results Both total fat area(TFA)and visceral fat area(VFA)were significantly reduced in“KURO-Oolong tea OTPP”group compared with placebo group. In addition, body weight,body mass index, body fat ratio, waist size, hip size and skinfold thickness were significantlyreduced in“KURO-Oolong tea OTPP”group. No adverse effects were obserbed in bothgroups.Conclusions The results of this study indicated that the intake of“KURO-Oolong teaOTPP”with a meal could be effective for prevention or amelioration of metabolic syndrome.
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薬理と治療 39巻10号, 901-910 (2011);
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Objective A randomized double-blind placebo-controlled study for 12 weeks was conductedon 48 subjects to evaluate the safety of the carbonated beverage containing resistantmaltodextrin in the case of long-term intake in healthy adults include the volunteers withmild hypertrigryceridemia(fasting serum trigryceride:150-199 mg/dL).Methods The subjects(male=24, female=24, mean 40.7±7.9 years old,)were randomlydivided into two groups, one is test group and the other is placebo group. The test groupingested daily 1 bottle of test beverage(resistant maltodextrin 5 g/bottle), which is equal toregular amount of recommended daily intake of the beverage, for 12 weeks. On the otherhand, the placebo group ingested the same amount of placebo beverage for the same duration.Results Statistically significant decrease in the body weight, BMI and body fat percentagein the test group and body fat percentage in the placebo group after 12 weeks of feedingwere observed, but these were not thought to be no clinically concerning changes. Changesin the vital sign, blood parameters and urine parameters were not observed during intakeperiod. No adverse event attributed to the test beverage was found in the study.Conclusions Thus, these results indicated the safety of the carbonated beverage containingresistant maltodextrin in healthy adults include the volunteers with mild hypertrigryceridemiain the case of long-term intake.