Volume 39,
Issue 12,
2011
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扉・目次
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Source:
薬理と治療 39巻12号, 993-995 (2011);
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TOPICS
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第10回CRCと臨床試験のあり方を考える会議2010 in 別府
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Source:
薬理と治療 39巻12号, 998-998 (2011);
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Source:
薬理と治療 39巻12号, 999-1000 (2011);
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Source:
薬理と治療 39巻12号, 1001-1002 (2011);
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Source:
薬理と治療 39巻12号, 1003-1004 (2011);
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Source:
薬理と治療 39巻12号, 1006-1006 (2011);
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Source:
薬理と治療 39巻12号, 1007-1008 (2011);
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Source:
薬理と治療 39巻12号, 1009-1010 (2011);
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Source:
薬理と治療 39巻12号, 1011-1012 (2011);
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Source:
薬理と治療 39巻12号, 1013-1014 (2011);
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DRUG PROFILE SERIES
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Source:
薬理と治療 39巻12号, 1017-1037 (2011);
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ORIGINAL ARTICLE
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Source:
薬理と治療 39巻12号, 1043-1054 (2011);
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Objective We have examined the efficacy of elastase enriched Natto on the healthy volunteer and slight hyperlipidemia patients. We also evaluated the safety of this product. Methods A double blind study was done with 90 persons whose blood lipid profile(LDL level) was higher than 120 mg/dL. The subjects were given either 45 g of elastase enriched Natto(1700 U/45 g)or same amount of standard Natto(860 U/45 g)twice a day for 12 weeks. Endpoints were settled with blood LDL level and total cholesterol, and blood samples were collected prior to a breakfast on each visit. Results There are no significant changes in LDL level between each group, but there are significant changes(8 W, 12 W)in each group compared to lead in period. Also total cholesterol level was reduced in each group. No adverse effects were observed in physical hematological biochemical parameters and subjective symptoms throughout the examination. Conclusions The data indicates that elastase enriched Natto has the potential to reduce not only LDL cholesterol levels but also total cholesterol levels in 12 weeks administration. These stable efficacy can be observed after 8 weeks administration.