薬理と治療
Volume 40, Issue 1, 2012
Volumes & issues:
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扉・目次
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TOPICS
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- 第10回CRCと臨床試験のあり方を考える会議 2010 in別府
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【CRC 連絡協議会主催特別企画/わが国における「CRC の養成研修」と「CRC と臨床試験のあり方を考える会議」の過去・現在・未来 座長総括】
40巻1号(2012);View Description Hide Description -
【CRC 連絡協議会主催特別企画/わが国における「CRC の養成研修」と「CRC と臨床試験のあり方を考える会議」の過去・現在・未来 講演】 厚生労働省事業におけるCRC 養成研修の経緯と実績-研修実施機関からの報告-
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【CRC 連絡協議会主催特別企画/わが国における「CRC の養成研修」と「CRC と臨床試験のあり方を考える会議」の過去・現在・未来 講演】 日本看護協会から
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【CRC 連絡協議会主催特別企画/わが国における「CRC の養成研修」と「CRC と臨床試験のあり方を考える会議」の過去・現在・未来 講演】 日本臨床衛生検査技師会から
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【CRC 連絡協議会主催特別企画/わが国における「CRC の養成研修」と「CRC と臨床試験のあり方を考える会議」の過去・現在・未来 講演】 日本臨床薬理学会認定CRC 制度について
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DRUG PROFILE SERIES
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国内初の選択的・可逆的・直接的にFⅩa を阻害する経口抗凝固薬エドキサバントシル酸塩水和物(リクシアナ錠 15 mg・30 mg)の基礎と臨床
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ORIGINAL ARTICLES
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意識障害を呈した脳神経外科患者に対するPhenytoin 投与量の検討
40巻1号(2012);View Description Hide DescriptionBackground Phenytoin(PHT), an anti-epileptic drug, displays non-linear pharmacokinetics at therapeutic blood concentration, and premeditated PHT dosage based on the weight of each patient should be administered to obtain therapeutic blood concentrations. Objective The purpose of this study was to analyze a correlation between the consciousness level of a neurosurgical patients and an adequate dosage of PHT. Methods A PHT dosage of 5 or 7 mg/kg/day was administered by dividing into twice a day (7:00 and 19:00)for one week in 20 neurosurgical patients. Each PHT dose was dissolved in 50 mL of saline and administered over 30 minutes. The PHT blood concentration was evaluated on days 4 and 8 day after initiating PHT therapy at 7:00 just before PHT administration. Results The PHT blood concentration at day 7 was 2.5±0.9 μg/mL in four patients given 5 mg/kg/day dosage, and was 11.6±2.2 μg/mL in 16 patients given 7 mg/kg/day dosage. Among the latter 16 higher dose patients, the PHT blood concentration on day 7 was 15.8± 2.5 μg/mL in patients with a score of 3 or lower on Japan coma scale(JCS), whereas it was 8.6±1.6 μg/mL in patients with a score of 10 or higher. Conclusions A PHT dosage of 7 mg/kg/day might be sufficient to acquire a therapeutic PHT blood concentration within one week;however, a higher dosage may be required when the patient has a JCS score of 10 or higher. -
ドネペジル塩酸塩 OD 錠 5 mg「日医工」およびドネペジル塩酸塩細粒 0.5%「日医工」の8 方向放射状迷路課題を用いたスコポラミン誘発健忘ラットに及ぼす作用
40巻1号(2012);View Description Hide DescriptionDonepezil hydrochloride OD Tablets 5 mg「Nichi-Iko」(Nichi-Iko Pharmaceutical Co.,Ltd.;Donepezil OD)and Donepezil hydrochloride F. G. 0.5%「Nichi-Iko」(Nichi-Iko Pharmaceutical Co., Ltd.;Donepezil FG)are developed by Nichi-Iko Pharmaceutical Co., Ltd. as generic drugs of Aricept D Tablets 5 mg(Eisai Co., Ltd.;Aricept D)and Aricept Fine Granules 0.5%(Eisai Co., Ltd.;Aricept FG), respectively, which are used for treatment of Alzheimer’s dementia. The improving effects for learning and memory deficit of these preparations on scopolamine-induced amnesia model in rats were studied in comparison with original drugs using an eight-arm radial maze task. The improving effects were evaluated with four endpoints, the number of working memory error, the running distance and time, and the rate of true choice. Scopolamine injection exhibited a significant increase in the number of working memory error, a significant prolongation of the running time and distance, and a significant decrease in the rate of true choice to confirm the induction of amnesia. Donepezil OD or Aricept D administration showed significant improving effects for learning and memory deficit on the scopolamine-induced amnesia model in all endpoints, and its efficacy of both drugs are comparable. Donepezil FG or Aricept FG administration also showed significant improving effects for learning and memory deficit on the scopolamine-induced amnesia model in all endpoints, and its efficacy of both drugs are comparable. These results suggest that Donepezil OD and Donepezil FG improved learning and memory deficit of the scopolamine-induced amnesia model and its efficacy is equal to Aricept D and Aricept FG, respectively.
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