薬理と治療
Volume 46, Issue 5, 2018
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TOPIC
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GUIDELINE
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ORIGINAL ARTICLES
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ニコチン曝露による腰痛モデルの確立およびワクシニアウイルス接種家兎炎症皮膚抽出液の効果
46巻5号(2018);View Description Hide DescriptionObjects We tried to establish a rat low back pain model using continuous infusion of nicotine, and examined the effect of a nonprotein extract isolated from inflamed skin of rabbits inoculated with vaccinia virus(Neurotropin(R))on gait abnormality and hyperalgesia of the model. Furthermore, we clarified the action mechanism of Neurotropin. Methods Rats were implanted subcutaneously with osmotic pumps filled with a nicotine solution. Walking time and 50% withdrawal pain threshold were measured using a rotarod device and von Frey filaments, respectively. The nicotine-treated rats were orally administered with Neurotropin, pregabalin, celecoxib, or limaprost daily from 2 to 7 weeks after nicotine exposure to assess the effect of drugs on behavior activities. To clarify the action mechanism of Neurotropin for these behavior activities in nicotine-induced low back pain model rats, the influence of intrathecal receptor antagonist for noradrenaline(NA)α2, 5-hydroxytryptamine (5-HT)2A, or 5-HT3 was examined. Results Walking time and 50% withdrawal pain threshold of nicotine-treated rats were decreased compared with sham rats. Limaprost and pregabalin ameliorated either walking time or 50% withdrawal pain threshold, but not both. Neurotropin improved both behavior parameters. NAα2, 5︱HT2A, or 5-HT3 receptor antagonist reduced the effect of Neurotropin on 50% withdrawal pain threshold but not walking time. Conclusion Sustained exposure to nicotine induced gait disturbance in addition to hyperalgesia in rats. The drug clinically used for neuropathic pain such as pregabalin was effective for hyperalgesia and the drug improving blood flow was effective for gait disturbance in this model. It was considered that Neurotropin improved hyperalgesia and gait abnormality by activating the descending pain inhibitory system and its blood flow improving action in nicotine-exposed rats. These results may suggest the usefulness of Neurotropin on patients with low back pain. -
α—グルコシダーゼ阻害薬ミグリトール(セイブル® 錠)の2 型糖尿病患者に対する安全性および有効性の検討―使用成績調査―
46巻5号(2018);View Description Hide DescriptionWe conducted a post-marketing prospective study of miglitol(SEIBULE(R)), an α-glucosidase inhibitor, over a 12-week observation period in Japanese patients with type 2 diabetes and examined its safety and efficacy. In this study, the case data were collected via a central registration method using an electronic data capture system. In the safety population(n=3273), 335 patients reported a total of 391 episodes of adverse drug reactions(ADRs); the incidence was 10.2%. The frequent ADRs were diarrhea(114 episodes), abdominal distension(62 episodes), and flatulence(32 episodes). Three cases of serious ADRs were noted: hypoglycemia, lacunar infarction, and liver dysfunction(1 patient each). The incidence of ADRs related to hepatic function disorder, including abnormal liver function test values, was 1.2%(39╱3273 patients), and no deterioration in liver function test values was observed. Furthermore, the incidence of ADRs did not increase in patients with liver disorder, renal disorder, and those aged 65 years or older; thus, miglitol could be used safely in these patients. In terms of efficacy, the amount of changes in HbA1c value and casual blood glucose, fasting blood glucose, 1 h post-load blood glucose, and 2 h post-load blood glucose levels at 12 weeks after the administration of miglitol was -0.66% and -28.9, -19.3, -63.1, and -43.5 mg╱dL, respectively, which indicated significant differences(P<0.05). These results show that miglitol is clinically safe and effective for use in patients with type 2 diabetes. -
肝機能障害を有する2 型糖尿病患者に対するα—グルコシダーゼ阻害薬ミグリトール(セイブル® 錠)の安全性および有効性の検討―特定使用成績調査―
46巻5号(2018);View Description Hide DescriptionWe conducted a post-marketing prospective study of miglitol(SEIBULE(R)), an α-glucosidase inhibitor, over a 24-week observation period in Japanese patients with type 2 diabetes and liver dysfunction, and examined its safety and efficacy, with particular focus on the presence or absence of fatty liver. In this study, the case data were collected via a central registration method using an electronic data capture system. Before administration, the mean AST and ALT levels in the safety population(n=156) was 49.6 and 64.1 U╱L, respectively. In the safety population, 19 patients reported a total of 27 episodes of adverse drug reactions(ADRs);the incidence was 12.2%. The frequent ADRs were diarrhea(11 episodes) and abdominal distension(4 episodes). No serious ADRs were observed. The incidence of ADRs did not increase in patients with type 2 diabetes and fatty liver. In addition, neither severe liver dysfunction nor abnormal liver function test values nor new safety problems were observed in patients with type 2 diabetes and fatty liver. Furthermore, in cases with fatty liver, at 24 weeks after the amount of changes in AST and ALT levels was -14.1 and -18.1 U╱L, respectively; these values indicated significant differences(P<0.05). In terms of efficacy, the amount of changes in HbA1c value and fasting blood glucose level at 24 weeks after the administration of miglitol was -0.69% and -12.8 mg╱dL, respectively, HbA1c value and fasting blood glucose level indicated significant differences(P<0.05). Whereas in cases with fatty liver, the amount of changes in HbA1c value and fasting blood glucose level was -0.77% and -14.5 mg╱dL, respectively; these values indicated significant differences(P<0.05) These results show that miglitol is clinically safe and effective for use in patients with type 2 diabetes and relatively mild liver dysfunction, and did not indicate any problems, regardless of the presence or absence of fatty liver. -
糖尿病患者に対するα—グルコシダーゼ阻害薬ミグリトール(セイブル® 錠)とインスリン製剤との長期併用における安全性および有効性の検討―特定使用成績調査―
46巻5号(2018);View Description Hide DescriptionWe conducted a post-marketing prospective study of long-term use(52 weeks)of miglitol (SEIBULE(R)), an α-glucosidase inhibitor, in combination with insulin therapy in Japanese patients with type 1 diabetes and type 2 diabetes, and examined its safety and efficacy. In this study, the case data were collected via a central registration method using an electronic data capture system. In the safety population(n=568), 198 patients reported a total of 242 episodes of adverse drug reactions(ADRs); the incidence was 34.9%. The frequent ADRs were hypoglycemia(104 episodes), diarrhea(33 episodes), and abdominal distension(23 episodes). Five serious ADRs were noted: cerebral infarction, lymphoma, hypoglycemia, hypoglycemic unconsciousness, and hepatobiliary disorders(in 1 patient each). The incidence of ADRs in patients with type 1 and type 2 diabetes was 45.6%(26╱57 patients)and 33.6%(170╱506 cases), respectively. The incidence of hypoglycemia in patients with type 1 and type 2 diabetes was 36.8%(21╱57 patients)and 16.2%(82╱506 cases), respectively. Both incidences were lower than those observed in clinical trials in combination with insulin therapy. No problems were observed after the development of hypoglycemia, gastrointestinal disorders, liver dysfunction, and severe cardiovascular disorders. At 52 weeks after the administration of miglitol to patients with type 1 diabetes, the amount of changes in HbA1c and casual blood glucose and fasting blood glucose levels was -0.35% and -23.8 and -86.0 mg╱dL, respectively. Whereas in patients with type 2 diabetes, the amount of changes was -0.66% and -37.9 and -22.4 mg╱dL, respectively;which indicated significant differences(P<0.05). These results show that miglitol is clinically safe and effective for long-term use in patients with type 1 and type 2 diabetes in combination with insulin therapy. -
健常成人におけるGABA 経口摂取が睡眠に与える影響―無作為化二重盲検プラセボ対照クロスオーバー試験―
46巻5号(2018);View Description Hide DescriptionObjectives This study aims to evaluate the effects of orally administrated GABA for 2 consecutive weeks on stress, sleep quality, fatigue, and electroencephalography during sleep compared to placebo. Methods A total of 32 subjects received, in random order, 100 mg of GABA or placebo 30-60 minutes before bedtime. A crossover design was used so that each subject received each of the 2 foods for a 2-week period(with a 2-week washout period between). Electroencephalograms were recorded during sleep at home with a portable device. This study was registered in UMIN-CTR(UMIN000026673). Results GABA significantly decreased the total non-rapid eye movement(non-REM)sleep stage 2. In stratified analysis based on stress, the total time of non-REM sleep stage 3 in the layer above the mean value of confusion-bewilderment, anger-hostility, tension-anxiety, total mood disturbance score of the Profile of Mood States 2nd edition(POMS2)were significantly increased in the GABA intake period compared to the placebo. In stratified analysis by fatigue feeling, the total time of non-REM sleep stage 3 at the time of ingesting GABA in the layer where the fatigue VAS prior to ingestion exceeded the average value significantly increased compared to placebo. Stratified analysis based on age, the total time of non-REM sleep stage 3 at the time of ingestion of GABA in the stratum above the average age was significantly increased compared to placebo. Conclusions These results indicate that oral administration of GABA increases the time of deep non-REM sleep of those who feel strong psychological stress or fatigue and╱or those who middle-aged and elderly. -
L—シトルリン含有食品の冷え改善効果―プラセボ対照ランダム化二重盲検クロスオーバー比較試験―
46巻5号(2018);View Description Hide DescriptionObjectives In the study, we evaluate the improvement effect of supplemented L-citrulline on sensitivity of cold in females. Methods We conducted a randomized, placebo-controlled, double-blind, crossover study for 25 healthy adult females who complain of feel coldness. Subjects were consumed either tablets containing 800 mg L-citrulline as test food, or containing maltose instead of L-citrulline as placebo food once a day for two consecutive weeks. The subjects visited the clinic on the 14th day consuming the test or placebo food. In each visit, subjects participated cold exposure test measured the skin surface temperature of specific points of left hand and a bodily sensation by the Visual Analogue Scale (VAS)for feeling of coldness at before exposure, just after exposure, 10, 20, 30, and 60 min after exposure. Results In the result of cold exposure test, the temperature of back of the hand and wrist in test food group was significantly higher than placebo food group at 10 min after exposure. In the temperature of wrist at 20 min after exposure, test food group was shown significantly higher than placebo food group. The sensation of cold in the hand in test food group was shown significantly low value compared with placebo food at 30 min after exposure. Conclusions These results suggest that a tablet containing L-citrulline would be useful for improving sensitivity of cold. -
こんにゃくセラミド含有食品の摂取による肌の保湿性をはじめとする肌諸症状改善試験―無作為化二重盲検プラセボ対照並行群間比較―
46巻5号(2018);View Description Hide DescriptionBackground It has been reported that oral intake of 1.8 mg╱day of glucosylceramides from Amorphophallus konjac(Konjac Ceramides)improved transepidermal water loss (TEWL)in healthy subjects, but there is no report regarding on the lower dose than previous reports. So we made an attempt to investigate the effects of lower dose, 0.6 mg╱day and 1.2 mg╱day of Konjac Ceramides. Methods A randomized double-blind parallel-group placebo-controlled comparison study for 12 weeks was conducted with healthy 35 to 59 years old males and females conscious of the skin dryness, roughness and sag. That was conducted as skin tests following, skin moisture content, skin moisture transpiration amount, skin elasticity, skin pH, skin color measurement, stratum corneum analysis, skin condition analysis, subjective symptoms questionnaire and finding by a dermatologist. Results TEWL values on the right cheek and the right elbow in 0.6 mg╱day intake group, and on the right cheek, the upper part of back and the right dorsum of foot in 1.2 mg╱day intake group were significantly decreased after intake in comparison to the control group. According to the results of the questionnaire survey on the skin conditions, 1.2 mg╱day intake group subjects significantly felt the improvement of their skin moisture and skin texture. In addition, no side effects or adverse events and no problems were confirmed during the examination. Conclusions These results suggested that oral intake of low dose, 0.6 mg╱day and 1.2 mg╱day Konjac Ceramide improved the skin condition and 1.2 mg╱day intake group subjects felt the improvement of their skin conditions. -
健常な成人男女を対象としたクロセチンの長期摂取安全性試験―ランダム化二重盲検プラセボ対照並行群間比較試験―
46巻5号(2018);View Description Hide DescriptionObjective Crocetin, a type of carotenoid, is a yellow pigment found in Gardenia fruits. The purpose of this study was to evaluate the safety of long-term intake of crocetin in healthy adult volunteers. Methods This study was a randomized, double-blind, placebo-controlled, parallel-group comparison trial. A total of 32 volunteers were randomly assigned to one of two treatment groups. The first group took a crocetin capsule(7.5 mg per capsule), and the second took a placebo capsule, once per day for 12 consecutive weeks. The safety of crocetin intake was evaluated by analyzing physical examination, blood biochemistry, hematology, and urine. Results The long-term intake of crocetin caused significant changes on safety parameters;however, the changes were sporadic. Small variations within the normal range were observed on blood biochemistry analyses and hematological tests, which were considered clinically insignificant and unrelated to the treatment. Therefore, no crocetin-related adverse changes were observed in the participants of this study. Conclusion The long-term intake of crocetin(7.5 mg╱day)was safe under the conditions of this study. -
5—アミノレブリン酸含有食品の老化皮膚性状に及ぼす効果―無作為化二重盲検プラセボ対照並行群間比較試験―
46巻5号(2018);View Description Hide DescriptionObjective The aim of the present study was to evaluate dermal effects of daily 5-aminolevulinic acid(ALA)supplementation. Methods The study was a 12-week randomized, double-blind, placebo-controlled trial on women aged 45-64 years complaining of skin dryness. Forty-five participants were randomly assigned to receive ALA︱free placebo, low-dose ALA supplement(25 mg╱day of ALA phosphate), or high-dose ALA supplement(50 mg╱day of ALA phosphate)daily for 12 weeks. We evaluated the skin collagen density and the stratum corneum hydration(SCH)on the cheek and the volar forearm using an ultrasound apparatus(DermaLab(R))and a Corneometer(R), respectively. Results Analyses of the total evaluable population revealed that low-dose and╱or high-dose ALA intakes were likely to increase the collagen density on the cheek, particularly after 8 weeks on women taking the high-dose ALA compared to the baseline levels(P<0.05), whereas these ALA intakes had no significant effects on the SCH either on the cheek or on the volar forearm throughout the intervention. However, in the ad hoc subgroup analysis, there was a trend for high-dose ALA intakes to increase the SCH in the older subpopulation(55-64 years). We observed a more promising change(P=0.061)in the SCH on the volar forearm after 12 weeks of treatment. ALA at both doses was well tolerated, without any reported untoward side effects. Conclusion Although our results are not final, they suggest that ALA supplement may increase the dermal collagen density in healthy middle-aged women in addition to increasing skin hydration, particularly among the older subpopulation. -
Effects of a Dietary Supplement Containing Water Chestnut Extract and Lutein on Quantified VDT Workload—affected Visual Function in Healthy Middle—aged Adults ―A Randomized, Double‒masked, Placebo‒controlled, Parallel‒group Intervention Study―
46巻5号(2018);View Description Hide DescriptionBackground Unfavorable changes in visual function due to visual display terminal(VDT) light exposures has become an increasing health problem. In this human study, we used a newly developed dietary supplement containing water chestnut extract(WCE)and lutein as potentially active ingredients(WCE-L diet), and examined its effects on quantified VDT workload-affected visual function. Methods A randomized, double-masked, placebo-controlled, parallel-group intervention study was conducted on 110 healthy middle-aged adults with visual fatigue complaints. Fifty-five each subjects were assigned to receive either WCE -L diet(in daily doses of 100 and 15 mg as WCE and lutein, respectively)or placebo for 12 weeks. To evaluate the effect on visual function, five ophthalmic parameters comprising near point of accommodation (NPA), spherical and cylindrical lens values, and near and distant best corrected visual acuities(BCVAs)were measured before and after the quantified VDT workload at baseline and at weeks 4, 8, and 12 of intervention. Results WCE-L diet supplementation caused no intervention-related adverse event nor laboratory test abnormality over the intervention period. In the analysis on the whole study population(n=110), changes from baseline in values of VDT workload-affected distant BCVA were significantly increased in WCE-L group compared with placebo group at all the three examination time points, while such a significant effect of WCE-L diet was not seen for any other ophthalmic parameters. Further exploratory analyses conducted by using ANCOVA within a subgroup of subjects with relatively stable and VDT workload︱sensitive NPA(n=60), suggested a favorable effect of WCE-L diet on NPA. Conclusion WCE-L diet was well tolerated and was shown to have the beneficial effect on visual acuity-related eye function and the potential for improving accommodation. -
コラーゲンペプチド摂取による膝関節の自覚症状へ及ぼす効果―ランダム化二重盲検プラセボ対照並行群間比較試験―
46巻5号(2018);View Description Hide DescriptionObjectives The aim of this study was to investigate the effect of a dietary supplement containing porcine skin collagen peptides on knee joint functions in subjects with pain and discomfort. Methods A randomized, double-blind, placebo -controlled parallel-group, comparison study was conducted in 30 healthy subjects (40-74 years old)with Kellegren-Lawrence grades of 0 orⅠ, without the diagnosis of osteoarthritis. They were randomly divided into two groups and administered with either the test product(125 mL drink containing 10 g collagen peptides derived from porcine skin)per day or the control product(placebo drink)for 12 weeks. The knee joint functions including pain and discomfort were evaluated using JKOM(Japanese Knee Osteoarthritis Measure)and the scores of locomo(locomotive syndrome)test. Results The scores of locomo test were not significantly changed. Interestingly, however, the JKOM Ⅳ criteria(general activities)was significantly improved at 12 week in the test product containing collagen peptides compared to the placebo group. Conclusions These result suggested that the daily supplementation of porcine skin collagen peptides is effective for improving QOL of the subjects with knee pain and discomfort. -
コラーゲンペプチド摂取による肌水分蒸散へ及ぼす効果―ランダム化二重盲検プラセボ対照並行群間比較試験―
46巻5号(2018);View Description Hide DescriptionObjectives The aim of this study was to investigate the effect of a dietary supplement containing porcine skin collagen peptides on skin in healthy subjects with dry skin. Methods A randomized, double blind, placebo-controlled study was conducted in 36 healthy subjects(30-60 years old)with dry skin. They were randomly divided into two groups and ingested either the test product(125 mL drink containing 10 g collagen peptides derived from porcine skin)per day or the control product(placebo drink)for 8 weeks. The outcomes about skin condition were evaluated using Trans-epidermal Water Loss(TEWL)of left upper arm. Results The increase of TEWL from the pretrial was significantly suppressed at 8 week in the test product containing collagen peptides compared to the placebo group. Conclusions These result suggested that the daily supplementation of collagen peptides derived from porcine skin is effective for skin moisture transpiration. -
黒大豆種皮抽出物含有食品の血管内皮機能改善効果の検討―ランダム化プラセボ対照二重盲検クロスオーバー試験―
46巻5号(2018);View Description Hide DescriptionObjectives Recently, the incidence of lifestyle-related diseases, such as hypertension, dyslipidemia and diabetes, is increasing according to the National Health and Nutrition Survey Japan, 2016. Arterial stiffness, which is accelerated by complications of these diseases, is one of the highest risk factors for cardiovascular and cerebrovascular diseases. Vascular endothelial cells secrete many vasoactive factors and protect vascular function; therefore, impaired endothelial vascular function indicates the early stage of arterial stiffness. The current randomized, double-blind, placebo-controlled, crossover study was conducted to investigate the effects of black soybean seed coat extract on improving endothelial vascular function. Methods Twenty-four healthy volunteers were randomized to oral administration of 100 mg of black soybean seed coat extract(58 mg as black soybean polyphenols)or placebo for 4 weeks. We measured the % of forearm blood flow╱basal forearm blood flow(%FBF), whichreflects endothelial vascular function, using strain gauge plethysmography. Results The black soybean seed coat extract group had a significantly higher % FBF compared with the placebo group after 4-week administration, demonstrating that black soybean seed coat extract improved endothelial vascular function. In the safety evaluation, no adverse events were observed related to the test foods.Conclusions These results suggest that black soybean seed coat extract is a useful food material to improve and maintain endothelial vascular function in healthy people. -
A Study for Evaluating the Effect of Bilberry Extrac tSupplement on Eye Conditions and Functions―A Randomized, Placebo—controlled, Double—blind Study―
46巻5号(2018);View Description Hide DescriptionObjective The objective of this study is to examine how the ingestion of a supplement containing bilberry extract“, Kita-no-kuni kara todoita blueberry”(“KB”)contributes to eye conditions and functions. Methods A randomized, placebo-controlled, double-blind study was conducted to elucidate the effect of the supplement. In this study we measured the visual analog scale (VAS)as the primary outcome. We also evaluated the critical flicker fusion frequency(CFF)and accommodation ability such as near point distance(NPD)and diopter(D)as the secondary outcome. These were measured 3 times(pre- and post-reading pages aloud and VDT work, after the rest)on every visit. Moreover adverse events were collected by means of a written questionnaire during the study. Results From all of 76 applicants, 28 were eliminated due to not meeting inclusion criteria and 1 declined to participate. After 47 subjects were randomly assigned to an intervention group, 4 declined to participate, thus 43 made a start with ingestion. 3 subjects discontinued due to personal reasons, and the remaining 40 subjects completed the study. 1 was eliminated because of inadequacy of the VAS documentation, data obtained with 39 subjects(KB 21, Placebo 18)was used for the analysis of efficacy. After 12-weeks of ingestion, the intergroup analysis showed a significant difference in VAS of“Eye strain”for the previous week. In addition, a significant difference was depicted in CFF differences of measured values between two groups. No adverse events were observed during a 12-week ingestion period. Conclusion We found out that the ingestion of KB for 12 weeks resulted in recovery from eye fatigue. -
健常者を対象としたBacillus subtilis C—3102 株含有食品の長期摂取における安全性―二重盲検ランダム化プラセボ対照並行群間比較試験―
46巻5号(2018);View Description Hide DescriptionObjective Ingestion of Bacillus subtilis C-3102 is expected to regulate the intestinal environment. We evaluated the safety of long-term administration of B. subtilis C-3102-containing food in a randomized, double-blind, placebo-controlled, parallel-group study. Methods Forty healthy Japanese subjects were randomly allocated into either C-3102 group or placebo group(20 subjects each). The subjects took either B. subtilis C-3102(4.0⊠109 cfu╱day)or placebo food, with water, after breakfast for 12 weeks. The safety evaluation included physical examination, urinalysis, blood analysis, a questionnaire, diary of bowel movement, and a medical questionnaire by the physician. Results Three subjects(two from the C-3102 group and one from the placebo group)were lost to follow-up and excluded from the analysis. Of the 37 subjects included in the analysis, 18 were from the C-3102 group(9 male, 9 female, mean age and standard deviation[SD]of48.9±14.7 years), and 19 subjects were from the placebo group(10 male, 9 female, mean age and SD of 48.5±12.0 years). No safety concerns were observed during the intervention period. Conclusions The present study demonstrated that long-term administration of B. subtilis C-3102-containing food in healthy subjects was safe under the conditions of the study. Trial registration UMIN-CTR: UMIN000028195 -
乳酸菌S—PT84 株の継続摂取による腹部脂肪低減効果とその安全性の検討―ランダム化二重盲検プラセボ対照並行群間比較試験―
46巻5号(2018);View Description Hide DescriptionObjective The aim of this study was to elucidate the effect of supplementation of 10 billion Lactobacillus pentosus strain S-PT84(S-PT84)on the abdominal fat mass reduction and its safety in human. Methods We performed a randomized, double-blind, placebo-controlled trial. One hundred thirty Japanese subjects aged over 20 years old with a body mass index(BMI)of 25 to below 30 were randomly divided into two groups and were administered either S-PT84(1.0⊠1010 cells╱day)or matching placebo once a day for 12 weeks. Abdominal fat area was measured by computerized tomography before and after the 12 week supplementation in both groups. Results Total fat area(TFA)and subcutaneous fat area(SFA)in S-PT84 group were significantly decreased greater than those in placebo group. A significant reduction was not observed in visceral fat area (VFA)after 12 weeks in S-PT84 group compared with placebo group. In the subjects which have less than 100 cm2 VFA, significant reduction was observed in TFA and SFA in S-PT84 group compared to placebo group. No adverse effects were observed in both groups. Conclusions The present results indicate that the supplementation of 10 billion S-PT84 decreased abdominal fat in Japanese subjects. -
パッションフルーツ種子エキスの健常成人における過剰摂取安全性試験―オープン試験―
46巻5号(2018);View Description Hide DescriptionObjective The aim of this study was to evaluate the safety of passion fruit seed extract in adult humans. Methods In this open-label trial, 11 healthy adult volunteers(45.0±14.9 years old)daily received the test beverage containing 27.3 g of passion fruit seed extract(containing 100 mg of piceatannol)for 4 weeks. Results There were no adverse events during the study. All subjects completed the study without abnormal changes in physical examinations, hematological analyses, blood biochemical tests, or urinary analyses. Conclusion These results showed that the beverage containing passion fruits seed extract, containing 100 mg of piceatannol, was safe. -
陸上長距離選手の筋損傷,貧血に及ぼす乳タンパク質・微量元素・ビタミン摂取の影響―前後比較介入試験―
46巻5号(2018);View Description Hide DescriptionObjective We investigated the effect of nutritional intervention with milk protein, minerals and vitamins to the muscle damage and anemia state of long-distance runners. Methods A before-after intervention study was conducted in 16 male university long distance runners. The runners were supplied the two types of test drinks, milk protein-enriched drink (Meiji Sports Milk, Milk Protein Up 200 mL)and minerals and vitamins-enriched drink(Meiji Meibalance(R) VitaZcs)for 8 weeks. The body weight, the muscle weight and the body fat percentage were measured before and 4, 8 weeks after from starting nutritional intervention. Bloodsamples were taken before and 4, 8 weeks after from starting nutritional intervention, and blood and serum parameters were measured. Results The body weight and the weight of muscle after intervention were increased and the body fat percentage was decreased compared with before intervention. Serum total protein, albumin, red blood cells, blood hemoglobin, serum copper and zinc levels after intervention were significantly higher than before nutritional intervention. Serum creatine kinase and lactate dehydrogenase levels were significantly lower than before nutritional intervention. Conclusions These data indicated that the supplement of milk protein, minerals and vitamins are effective to the suppression of muscle damage and the prevention of anemia state.
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