Therapeutic Research

Abstract

Objective: The present study examines the effect of percutaneous coronary intervention(PCI) on cardio –pulmonary functional reserve(CPR) and outcomes of the inclination of the exponential curve –fitting model for oxygen uptake and heart rate during graded treadmill exercise(I –ECOH) and then investigates whether I –ECOH is useful for evaluating patients with ischemic heart disease(IHD). Subjects and Methods: Ten patients with effort angina were assigned to one group in whom revascularization was maintained(MR group; n=5), and another in whom>75% restenosis occurred(RS group; n=5) according to coronary angiography(CAG) findings at six months after PCI. The graded maximal exercise test proceeded within five weeks before and within six months after PCI. Results: Peak oxygen uptake(V4O2 peak) and peak hear t rate(HR peak) were significantly higher and I –ECOH was significantly lower after PCI in the MR group whereas no parameters significantly changed after PCI in the RS group. Conclusion: I –ECOH can objectively evaluate CPR at a submaximal exercise level and it might also be appropriate for evaluating changes in CPR associated with ischemia improved by PCI.