Therapeutic Research

Abstract

The blood of eicosapentaenoic acid/arachidonic acid(EPA/AA) ratio is proportional to the efficacy of primary and secondary prevention of ischemic heart diseases(IHD).Purpose:The relationship between coronary artery plaque ROI (I/U) by MDCT(multi detector –row computed tomography)and the coronary risk factors as risks for acute coronary syndrome(ACS)was evaluated. Methods:The 42 patients with IHD were investigated, 26 with ACS and 16 with angina pectoris(AP). MDCT and serum parameter of the acute stage were measured. 11 coronary branches according to the AHA classification were examined for plaque count, calcification, plaque ROI with MDCT image. Results:No significant differences were noted between plaques count and calcifications for ACS and AP. However, the plaque ROI for the culprit vessels with AP was 87.8±29.4, but with ACS was 37.2±35.0(p<0.001). The plaque ROI for those vessels with AP was 76.2±30.4 and 33.4±27.0 with ACS(p<0.001). The EPA/AA ratio was 0.62±0.2 with AP, but with ACS was 0.44±0.2(p=0.027).Conclusion:In ACS, unstable plaques are scattered not only in the culprit vessels, but even in other vessels. It was suggested that EPA/AA ratio was a useful marker for the vulnerable plaques.