Therapeutic Research

Abstract

Objectives：The optimal regimen of post dual antiplatelet therapy（DAPT）monotherapy is not yet established. We conducted an exploratory study to assess the effectiveness of prasugrel monotherapy after short‒term DAPT in patients for whom long‒term aspirin therapy was not recommended. 　　Methods：Fifty‒six patients underwent percutaneous coronary intervention and received prasugrel monotherapy for 6 months after short‒term DAPT. Coronary ischemia and stenosis were evaluated by computed tomography（CT）and CT‒derived fractional flow reserve before and after prasugrel monotherapy. 　　Results：No cardiovascular or bleeding events occurred. No adverse events related to prasugrel monotherapy after short‒term DAPT occurred. 　　Conclusions：Prasugrel monotherapy after short term DAPT may be effective in patients for whom long‒term aspirin therapy is not recommended.