Therapeutic Research

Abstract

Objective： The current study aimed to investigate the achievement rate of target blood pressure（BP）, and factors associated with nonachievement of target BP in patients with chronic kidney disease（CKD）on antithrombotic therapy. 　Methods： This cross‒sectional study was conducted at an outpatient clinic in 2018. Of 2427 outpatients who received antithrombotic therapy, patients without CKD, those with CKD stage 5 or on hemodialysis and those with missing data on body mass index, urinalysis results and estimated glomerular filtration rate were excluded from the study. Finally, 786 outpatients met the inclusion criteria. Clinical parameters were obtained from the center’s electronic database. The target office BP was set at＜130/80 mmHg in patients with CKD on antithrombotic therapy.　Results： Approximately 59％ of patients had a BP of＜140/90 mmHg, and only 30.3％ achieved the target BP of＜130/80 mmHg. Multivariable logistic regression analyses indicated that obesity and proteinuria were significantly correlated with nonachievement of target BP. Moreover, heart failure and cerebrovascular disease were negatively associated with nonachievement of target BP. 　Conclusions： Only a small proportion of patients with CKD on antithrombotic therapy achieved the target BP. Obesity and proteinuria were associated with nonachievement of the target BP in patients with CKD on antithrombotic therapy.