Therapeutic Research

Abstract

Background：The present study utilizes the human sensory evaluation of bilastine ODTs for medication guidance. Furthermore, we measured the changes in the bitter taste of dissolved bilastine ODTs over time by using a taste sensor（TS‒5000Z）. 　　Methods：We collected their medicine instruction records ①　ease of taking bilastine ODTs and ②　their taste. In order to evaluate the taste of bilastine ODTs upon dissolution over time, we measured the changes in sensor response at 15, 30, 60, 300 and 1800 seconds using a bitter taste sensor（BT0）. 　　Results：Of the 78 patients studied, 66（84.6％）responded“It is easy to take the drug,”and 68（87.2％）responded“I do not mind the taste of the drug.” 　　The reasons for the response“It is difficult to take the drug.”were：“I taste a peculiar bitterness, and it is bothersome as it remains in my mouth for a while,”and“Sweet taste is not really my favorite.” 　The sensor response measured by the BT0 sensor increased at 15, 30, and 60 seconds and became constant after 300 seconds. 　　Conclusion：Taste was suggested to be one of the reasons for the response“It is difficult to take the drug.”On the other hand, the sensor response measured by the BT0 sensor increased at 15, 30, and 60 seconds, suggesting that the taste evaluation was influenced by the difference in drug residence time in the oral cavity due to the patient’s medication status.