Therapeutic Research

Abstract

Introduction: Severe aortic regurgitation(AR) often leads to left ventricular remodeling and functional mitral regurgitation(FMR), exacerbating heart failure. We present a case of successful management of severe heart failure secondary to FMR resulting from advanced AR through percutaneous mitral valve repair, along with a literature review. Method: An 81 –year–old male with symptoms of heart failure and a history of chronic AR was admitted with worsening heart failure. Despite conventional therapy, his condition deteriorated, prompting consideration of percutaneous mitral valve repair using Mitra-ClipTM. Result: Postoperative evaluation showed improvement in mitral regurgitation to mild–to –moderate, with a mean mitral valve pressure gradient of 5.4 mmHg. The patient’s symptoms improved significantly, and he was discharged without recurrent heart failure exacerbation. Discussion: Advanced AR often leads to FMR and worsens the prognosis. Surgical intervention is recommended for patients with symptomatic heart failure and reduced left ventricular function, but in this case, percutaneous mitral valve repair was chosen due to high surgical risk and patient preference. Despite the lack of established efficacy in severe AR, MitraClipTM resulted in improved hemodynamics and heart failure symptoms. This case highlights the potential of percutaneous mitral valve repair as an effective alternative for managing severe heart failure secondary to FMR in advanced AR. Further research is warranted to evaluate its efficacy in this population. Conclusion: Percutaneous mitral valve repair with MitraClipTM effectively managed severe heart failure secondary to FMR in advanced AR, demonstrating significant improvement in symptoms and hemodynamics.