薬理と治療

Abstract

Test drinks termed“milk added liquid coffee”containing mannooligosaccharides from coffee mannan were administered to 48 healthy volunteers, and the effect on body fat reduction was investigated. Volunteers were divided into two groups for a placebo controlled double blind parallel test. Milk added liquid coffee（275 g）containing 3.0 g mannooligosaccharides or dextrin（as the placebo）was consumed each day by volunteers for 16 weeks. Physical examination was accompanied by measurements of blood indices, abdominal fat area as determined by computed tomography（CT）scan, and total body fat as determined by dual energy X−ray absorptiometry（DEXA）. Abdominal total fat area in the test group was significantly reduced compared with the same subjects before administration and with the placebo group（both p＜0.001）. Furthermore, waist size, arm skinfold thickness, back skinfold thickness and total body fat mass in the test group showed a significant reduction over the 16 week period（p＜0.001, p＜0.01, p＜0.001 and p＜0.05, respectively）. These results suggest that milk added liquid coffee containing mannooligosaccharides reduces human abdominal fat. （Jpn Pharmacol Ther 2008；36：541−8）KEY WORDS Mannooligosaccharides, Milk added liquid coffee, Abdominal fat area, Total body fat mass