薬理と治療

Abstract

Objectives Chicken collagen hydrolysate（Chicken−Collagen Octa Peptides；C−COP）contains a peptide（Gly−Ala−Hyp−Gly−Leu−Hyp−Gly−Pro）with an inhibitory effect of angiotensin converting enzyme（ACE）. Four weeks of C−COP administration at 2.9 g／day has already been found to reduce blood pressure in humans. Here, we investigated both efficacy and safety of a long−term administration（12 weeks）of a lactic acid beverage containing C−COP. Methods A total of 120 subjects with either mild hypertension or high−normal blood pressure were randomly assigned to 2 groups：a test−food group in which subjects were given a lactic acid drink containing C−COP at 2.9 g／day, and a placebo group in which subjects were given a dummy drink. The study period comprised a total of 18 weeks：2 observational weeks before the treatment, a 12−week treatment period, and 4 weeks for the post−treatment observation to investigate the parameters related to hypotensive effects and safety. Results Systolic blood pressure in the test−food group was significantly reduced compared with that in the placebo group. In addition, when compared with the baseline values, blood pressure was continuously reduced from 2 weeks after onset of administration in the test food group. No clinically meaningful adverse effects or abnormal changes in laboratory results were observed.Conclusion These results suggest that the lactic acid beverage containing C−COP is a useful food because it safely reduced blood pressure in subjects with mild hypertension or highnormal blood pressure.（Jpn Pharmacol Ther 2008；36：561−75）KEY WORDS C−COP（Chicken−Collagen Octa Peptides）, ACE−inhibitory activity, Longterm administration, Safety