薬理と治療

Abstract

Objectives To evaluate the clinical usefulness of BR−99S, a bicarbonated Ringer’s solution with magnesium. BR−99S is a kit product packaged in a plastic bag（direct container）using a gas−barrier film that keeps the stability of the solution by preventing carbon dioxide gas emission and pH elevation. Methods To assess preparation efficiency, 6 pharmacists compared formulation time between BR−99S and Ringer’s solution＋Maylon 84＋corrective use magnesium sulfate solution（RMM）. Also, to evaluate the usability of BR−99S, 10 pharmacists and 10 nurses filled out 13 questionnaires related to preparation efficiency, bacterial infection, medical malpractice, storage space, medical waste, and total usefulness. Results The average time needed to prepare one dose for a single patient was 76.0 sec for BR−99S and 226.2 sec for RMM. The average time needed to prepare one dose each for five patients was 241.0 sec for BR−99S and 662.2 sec for RMM. Both times were significantly shorter for BR−99S（p＜0.01）. In the usability questionnaire survey, all responses were significantly superior for BR−99S compared to RMM（p＜0.01）.Conclusion BR−99S is a bicarbonated Ringer’s solution with magnesium packaged in a plastic bag using a gas−barrier film that keeps the stability of the solution by preventing carbon dioxide gas emission and pH elevation. The time needed to prepare BR−99S was significantly shorter than that needed to prepare RMM. In the results of questionnaire survey, BR−99S was shown to prevent bacterial and foreign particle contamination, reduce medical malpractice, meet the speedy preparation for emergency use, and increase the quality of treatments. Based on the results of this study, BR−99S is thought to be useful as a kit product. （Jpn Pharmacol Ther 2008；36：593−602）KEY WORDS Bicarbonated Ringer’s solution, Magnesium, Kit product, Clinical usefulness