薬理と治療

Abstract

Objectives A randomized double−blind placebo−controlled crossover study was conducted on 26 subjects with mild hyperlipidemia to evaluate the suppressive effect of Pleurotus eryngii extract（PEE）on postprandial serum triacylglycerol（TG）elevation. Methods Subjects were Japanese adult male and female whose fasting TG levels were between 110〜275 mg/dL. Subjects were divided into two groups randomly, and ingested a high fat meal(40 g fat)with or without PEE. Serum TG levels were measured at 0, 1, 2, 3, 4, 5 hr after ingestion of the meal. Results Postprandial serum TG elevation of the high fat meal containing PEE was signifi- cantly suppressed at 3 hr and 4 hr after ingestion compared with the placebo fat meal. Rem- nant-like particles cholesterol(RLP-C)concentrations in serum were also significantly decreased at 2 hr and 4 hr. AAUCs(areas under the curves)of both serum TG and RLP-C levels were significantly decreased by 18.1%(p<0.05)and 24.1%(p<0.01), respectively. No significant differences in VLDL-TG and non-esterified fatty acids(NEFA)were observed. No adverse effects were observed. Conclusions PEE has considerable suppressive effect on the postprandial serum TG eleva- tion in the subjects with mild hyperlipidemia, suggesting that PEE may be useful for the risk reduction of obesity and obesity-related diseases. (Jpn Pharmacol Ther 2008;36:817-23) KEY WORDS Pleurotus eryngii, Lipase inhibitor, Postprandial serum triacylglycerol, Obesity