薬理と治療

Abstract

Objective We examined effect of placenta extract on the activities of hepatic sympathetic, adrenal sympathetic, pancreatic sympathetic and gastric vagal nerves in rats. Methods A polyethylene catheter was inserted into the duodenal cavity for intraduodenal injection. For recording efferent autonomic nerve activities, distal ends of the hepatic sympathetic nerve, adrenal sympathetic nerve, pancreatic sympathetic nerve, and the gastric branch of the ventral subdiaphragmatic vagal nerve were ligated and hooked to a pair of silver wire electrodes after laparotomy. Electrical changes in nerve activities were amplified, filtered and monitored on an oscilloscope. Results Intraduodenal injection of 10% placenta extract slightly but not significantly reduced the hepatic sympathetic nerve activity. Adrenal sympathetic nerve and pancreatic sympathetic nerve activities were significantly increased after intraduodenal injection of 10% placenta extract. On the other hand, 10% placenta extract significantly reduced the gastric vagal nerve activity. Conclusion The present results indicated that placenta extract has a modulatory effect on autonomic nerve activities, and this modulation some how be related to the physiological functions of placenta extract.