薬理と治療

Abstract

Objectives To evaluate the effect of carbonated beverage containing resistant maltodextrin on the postprandial serum triglyceride levels and the safety of long-term intake and excessive intake of the beverage. Methods For evaluation of the effect on postprandial serum triglyceride levels, a doubleblinded crossover study was performed. Ninety volunteers were randomly divided into two groups and ingested a fat-rich diet together with 1 bottle(350 mL)of the beverage that either did or did not contain resistant maltodextrin. Serum triglyceride levels were measured before and 2, 3, 4,and6 hours after ingestion. For the safety evaluations of long-term intake and excessive intake of the beverage, two double-blinded parallel group studies were performed respectively. Forty volunteers were randomly divided into two groups for each study, and took daily 1 bottle(350 mL)of the beverage that either did or did not contain resistant maltodextrin for 12 weeks(long-term intake)or 3 bottles of each beverage daily for 4 weeks (excessive intake). Results Intake of the beverage containing resistant maltodextrin significantly suppressed the elevation of postprandial serum triglyceride levels at 3 and 4 hours compared to levels with intake of placebo beverage(P<0.05). In the long-term and excessive intake trials, no abnormal changes attributed to ingestion of the test beverage in clinical findings such as laboratory blood test, urinalysis and physical examination were observed. Conclusion These results indicated that carbonated beverage containing resistant maltodextrin taken with a meal had an inhibitory effect on the postprandial serum triglyceride elevation and were safe for long-term and excessive intake.