薬理と治療

Abstract

In this study, soymilk fermented with Lactobacillus delbrueckii subsp. delbrueckii TUA4408L (TUA4408L)was used in an experimental diet to examine whether its intake affects i)stool frequency, ii)the number of days with bowel movement, iii)stool quantity, and iv)stool consistency. This single-blind study involving 21 female test subjects(mean age, 32.7±5.3 years)with a tendency for constipation was conducted in four 2-week-long phases, including i)an observational phase, ii)a control diet phase(intake of 90 g of a diet without soymilk and TUA4408L twice per day), iii)a resting phase, and iv)an experimental diet phase(intake of 90 g of the experimental diet containing soymilk and TUA4408L twice per day). According to the results, the number of days with bowel movement, stool frequency and stool quantity during the experimental diet phase increased significantly compared to those during the control diet phase(P<0.01or P<0.05). As for stool consistency, compared to the control diet phase, banana-like or toothpaste-like stool increased and hard, nut-like stool decreased during the experimental diet phase. In other words, there was an improvement in stool consistency. These results indicate that the intake of soymilk fermented with TUA4408L shows promise in improving bowel movement.