薬理と治療

Abstract

Objectives We developed a vinegar drink containing indigestible dextrin and mixed herbal extract. In this study, we investigated the effect of the vinegar drink on postprandial blood glucose level of volunteers.Methods We performed a double-blind cross-over trial. A total number of 32 volunteers(16men and 16 women:average age 48.6±8.5)whose postprandial blood glucose level increased more than 140 mg/dL, ingested a 140 mL of vinegar drink containing indigestible dextrin and mixed herbal extract or a placebo drink with white rice as a test meal. The blood glucose level was measured before and30, 60, 90 and 120minutes after the intake of test meal, and compared the changes between the vinegar drink group and placebo group. Results We observed no significant effect of the vinegar drink on postprandial blood glucose level of total 32 volunteers. However, with the exception of subjects with unstable blood glucose, we observed significant suppressive effect of the vinegar drink on the AUC value and the blood glucose level at 60 minutes after the intake of test meal. Conclusions These results suggest that the vinegar drink containing indigestible dextrin and mixed herbal extract may suppress the elevation of the postprandial blood glucose level in the subjects whose blood glucose level tends to rise.