薬理と治療

Abstract

Objective We examined the effect of catechins with a galloyl moiety to reduce dietary lipid absorption in humans. Methods A randomized double-blind placebo-controlled crossover study was conducted. The beverage(340 mL/bottle)contained 190.9 mg of tea catechins with a galloyl moiety. Fifteen healthy adult subjects were randomly divided into two groups. Group A was requested to consume the drinks, containing catechins with a galloyl moiety, everyday for 10 days and then the placebo for 10 days, after an 11 day interval between these intake periods. On the contrary, Group B consumed the placebo first for 10 days and then the catechin drinks for 10 days, after an 11 day interval between the periods. Each subject in the catechin group was given 3 bottles of the test beverage/day and each subject in the placebo group was given 3 bottles of the placebo beverage/day. During the treatment period, subjects were given the same menu(Male:2244±35.6 kcal, 84±0.6 g lipids, Female:1944±35.6 kcal, 66±0.6 g lipids)at each meal. On the last 3 days of each treatment period, feces were collected in order to measure the excretion of lipids. Results Lipid excretion into feces was found to be significantly higher in the test beverage consumption cases than in the placebo beverage ones on third day. Serum total cholesterol and LDL cholesterol were significantly lower in the test beverage consumption cases than in the placebo beverage ones. Conclusions Our present observations suggest that consumption of catechins with a galloyl moiety could increase lipid excretion into feces.