薬理と治療

Abstract

Objectives To evaluate the safety of long︱term intake and excessive intake of the carbonated beverage containing resistant maltodextrin. Trial design Randomized double-blinded placebo-controlling parallel-group comparison study Methods For the safety evaluations of long︱term intake and excessive intake of the carbonated beverage, double︱blinded parallel group studies were performed respectively. Forty volunteers were randomly divided into two groups for each study, and took daily 1 bottle（350mL）of the carbonated beverage that either did or did not contain resistant maltodextrin for 12 weeks （long-term intake）or 3 bottles of each beverage daily for 4 weeks（excessive intake）. Results In the long-term and excessive intake trials, no abnormal changes triggered by ingestion of the test beverage were observed in clinical findings such as laboratory blood test, urinalysis and physical examination. Conclusion These results indicated that the carbonated beverage containing resistant maltodextrin were safe for long-term and excessive intake.