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薬理と治療
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植物由来乳酸菌ミヤビスLB（Lactobacillus brevis）の摂取が唾液中免疫グロブリンA 分泌速度に軽度低下がみられる成人の免疫機能に及ぼす影響
JPY
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ライフサイエンス出版
Abstract
Objective The aim of this study was to evaluate the intake of lactic bacteria （Lactobacillus brevis Miyavis LB）on immune function in healthy adult volunteers with slightly reduced salivary secretory immunoglobulin A（sIgA）. Methods Eleven subjects（average of 41.0±10.1 years old）who had slightly reduced salivary sIgA received lactic bacteria（4 g；～4⊠1010 cells）daily for 8 weeks, and their immune functions, including salivary sIgA level, natural killer（NK）cell activity, and lymphocyte blastoid transformation, were evaluated. Results The intake of lactic bacteria for 8 weeks significantly increased NK cell activity （from 22.41±9.06％ to 41.32±14.21％）, concanavalin A︱stimulated lymphocyte blastoid transformation（from 31463.8±4146.3 cpm to 47744.0±4790.9 cpm；P＜0.05）. The level of salivary sIgA, however, was not significantly changed in this study. Conclusions The intake of lactic bacteria is suggested to enhance immune function in adult humans.
