薬理と治療

Abstract

Objective The aim of this study was to evaluate the effectiveness of indigestible dextrin-containing carbonated beverage on the postprandial increase in serum trigriceride level in subjects with moderately high fasting serum triglyceride levels. Methods Volunteers（90 subjects）with their fasting serum triglyceride levels of 110 -219 mg╱dL were enrolled in a randomized, double-blind, placebo-controlled, crossover study. Subjects ingested a high︱fat meal（42.2 g fat）together with either a test beverage containing 5 g（as dietary fiber）of indigestible dextrin or a placebo beverage without indigestible dextrin. Serum lipids were determined before and 1, 2, 3, 4, 5, and 6 hours after the high-fat meal ingestion. Results The ingestion of test beverage suppressed the postprandial increase in the serum triglyceride level compared to that in the placebo group. The difference was significant from 1 through 3 and 5 and 6 h following the ingestion（P＜0.05）. This change was accompanied by a difference in the area under the curve（AUC）for serum triglyceride levels（mean±SE：1648 ±53 mg╱h╱dL for test beverage group vs. 1747±57 mg╱h╱dL for placebo group；P＝0.027）. The increase in the postprandial remnant︱like lipoprotein particle cholesterol level was also suppressed by the ingestion of test beverage（change in AUC of 29.9±1.4 mg・ h╱dL vs. 33.5 ±1.5 mg・h╱dL for placebo, P＝0.006）. Conclusions The ingestion of indigestible dextrin︱containing carbonated beverage suppresses the increase in the postprandial serum triglyceride and remnant︱like lipoprotein particle cholesterol levels in subjects with moderately high fasting serum triglyceride levels.