薬理と治療

Abstract

Objective Effects of fish︱derived collagen peptide（FCP）on skin properties were investigated. Methods Placebo︱controlled double︱blind trial was conducted in Japanese women（35-65 years of age）with dry and saggy face skin. They ingested 5 g of placebo or FCP for 8 weeks, and skin properties and subjective feeling of skin conditions were examined before and after ingestion for 4 and 8 weeks. Results Decrease of wrinkle number was significantly larger（P＝0.034）in the FCP group than in the placebo group at 8 weeks by sub︱group analysis. In women with dry face skin, texture improved significantly（P＝0.010）in the FCP group than in the placebo group, and number of red areas showed tendency of improvement（P＝0.054）at 8 weeks in the FCP group compared to the placebo group. Inter-group significant difference（P＝0.008）was observed for subjective feeling of skin conditions at 8 weeks. Conclusions Ingestion of FCP improves skin properties and subjective feeling of skin conditions.