薬理と治療

Abstract

We investigated the effect of oral administration of Ganoderma lucidum（Reishi） extract at doses of 500 or 1000 mg／kg on hepatic injuries experimentally induced by D-galactosamine in male rats, an animal model of viral hepatitis. Oral administration of Reishi extract showed significant improvement on the serum-biochemical and histopathological suppressions in D-galactosamine-induced hepatic injury. In the D-galactosamine-treated rats, Reishi extract significantly prevented the increases in serum aspartate aminotransferase（GOT）, alanine aminotransferase（GPT）and alkaline phosphatase（ALP）activities in a dose-dependent manner, and also apparently improved hepatic cell necrosis. In addition, the Reishi extract showed the antagonizing effect on the increase of lipid peroxide and the decrease of triglyceride contents in serum. These findings suggest that oral administration of Reishi extract may have an ameliorating effect on hepatic dysfunction