薬理と治療

Abstract

The safety of excess intake of powdered green tea containing long pepper extract, which was taken at dosage three times the standard amount, was analyzed. The study was conducted in individuals with blood pressure in the normal range, high normal range and patients with first-degree hypertension. The subjects［10 subjects╱group, 30 subjects in tota（l male╱female＝24╱6, age＝22-63 years old）］took three packs of the test tea［powdered green tea containing 150 mg of long pepper extract（including 90μg of piperine）］once daily for 4 weeks. We observed systolic and diastolic blood pressures, side effect, adverse event, laboratory test data, body weight, and heart rate. Although both of systolic and diastolic blood pressures were a significant reduction compared to the baseline at each time-point of evaluation from Week 1 onward, these results were no individuals with hypotension. Also, although systolic and diastolic blood pressures at Week 4 recovered at Week 6（the period of observation after intake finished）compared to Week 4, these werenʼt exceed baseline. Any abnormal changes in clinical findings such as laboratory test, physical test, and adverse reactions were not observed. These results demonstrate that powdered green tea containing 150 mg of long pepper extract is safe, even when it is taken at an excess amount, because blood pressures and other tests showed no abnormal changes of clinical importance.