薬理と治療

Abstract

Background In recent years, there is greater use of the transdermal delivery system. Oxybutynin　has some interesting properties to treat overactive bladder. However, these medicines have　reportedly caused dermopathy. Methods Oxybutynin chloride tapes were applied to 7︱week︱old male hairless mice. The patches were removed after 24 hours, and the skin was observed after one hour. Dry skin mice are produced by organic agents. Various external medicines are particularly indicated in the management of dry skin applied tapes. The dermopathy was assayed mainly by transepidermal water loss and skin hydration. Results With oxybutynin chloride, greater skin damage was seen with tapes. These are especially for dry skin treatment. However, treatment of heparinoid relieved significant symptoms. Conclusions Experimental investigation has confirmed dermopathy. Even oxybutynin chloride tapes have a stronger effect on the skin than non-patch applications. This suggests that close attention to inflammation is needed in patients with the dry skin characteristics of elderly people. Furthermore clinical research, on the pre-application of moisturizing agents, is needed to identify appropriate tapes for transdermal delivery systems.