薬理と治療

Abstract

Objectives The objective of this study was to investigate the acute effect of Kaempferia parviflora extract on oxygen consumption and respiratory quotient（RQ）during rest and moderate exercise. A randomized double-blind placebo-controlled cross over study was conducted in the case of the single oral intake of Kaempferia parviflora extract in healthy volunteers. Methods We prepared the hard capsules containing a mixed powder of Kaempferia parviflora extract, dextrin and cyclodextrin for this clinical study. A randomized double-blind placebo-controlled cross over trial was conducted on 12 healthy volunteers（age 20 to 29 years old）. The subject ingested placebo or 50 mg Kaempferia parviflora extract（1 cupsule）30 minutes before moderate exercise（70％ stress of anaerobic threshold, 30 minutes）. Results After excluding deviants, the number of subjects analyzed was five. The single oral intake of Kaempferia parviflora extract increased oxygen consumption and significantly decreased RQ during moderate exercise, as compared with placebo. In addition, any clinical adverse events were not found through the study period. Conclusions These results suggest that the single oral intake of Kaempferia parviflora extract increased energy consumption and fat utilization rate without adverse reaction, and might support for prevention and improvement of obesity and metabolic syndrome.