薬理と治療

Abstract

Objective We examined effects of a food containing Shogaol“, Ginger Extract Powder S”, on a cold constitution in volunteers with a subjective symptom of poor circulation. Methods A 4-weeks study with 12 female subjects, whose age was 20-35 years old, was conducted as an open-label trial. At first cold-water exposure test was conducted during the non-ingestion period: core temperature was measured at before exposure, just after exposure, 5, 10, 15, 30 and 60 min after exposure（the non-ingestion period）. After one day washout, subjects ingested test food, participated cold︱water exposure test measured core temperature after single ingestion of the test food as with the case in the non-ingestion period（the single ingestion period）. The third cold-water exposure and measurement for core temperature were conducted after 4-weeks ingestion of the test food（the 4-weeks ingestion period）. Changes of core temperature, and a bodily sensation measured by the Visual Analogue Scale（VAS）were compared in each period. Results A result of analysis of core temperature, there was no significant change in the single ingestion period and the 4-weeks ingestion period compared with that in the non-ingestion period. On a variation of core temperature after cold-water exposure, the 4-weeks ingestion period showed significant inhabitation of decreasing body temperature compared with that in the non-ingestion period at 15, 30, and 60 min after cold-water exposure. On a result of VAS, the 4-weeks ingestion period showed significant improvement with items（“coldness of body”, “leg swelling”“, face swelling”“, bad makeup application”“, poor digestion”, and“ languidness”） compared with those in the non-ingestion period. Conclusion These results imply that a food containing Shogaol would be useful for improving a cold constitution.