薬理と治療

Abstract

Objectives　To evaluate the efficacy of glucosylceramide extracted from pineapple for the skin, a randomized, double-blind, placebo-controlled, parallel-group trial was conducted on healthy volunteers who are concerned about dullness and dryness of their skin. Methods　Seventy adult subjects（Japanese men and women aged 20-59 years）were randomly assigned to receive either a tablet containing 1.2 mg of glucosylceramide extracted from pineapple or a placebo once daily for 12 weeks. The primary endpoints included transepidermal water loss（TEWL）, skin moisture content, color difference（L＊ value, a＊ value, b＊ value）, and skin texture. A safety assessment as a secondary endpoint was also performed by interview with a medical doctor. Results　After excluding deviants, the number of subjects analyzed was 61. In the group which took the tablet containing 1.2 mg of glucosylceramide extracted from pineapple, TEWL was significantly decreased and the L＊ value was significantly increased after ingestion for 12 weeks. In addition, any clinical adverse events were not found throughout the study period. Conclusion　The present study suggests that daily consumption of glucosylceramide extracted from pineapple could improve barrier function and tone of the skin.