薬理と治療

Abstract

Objective This study was undertaken to evaluate the effects of the glucosyl hesperidin （GHes）intake on skin color and skin conditions in Japanese women. Methods A randomized, placebo-controlled, double-blind trial was conducted on 42 subjects （35-55 years of age）. They ingested 500 mg of GHes or placebo once daily for 12 weeks. The properties of facial skin were measured at 0 （baseline）, 6 and 12 weeks of intake period. Results When each parameter was analyzed based on the amount of change from baseline （Δ）, a＊（redness）and Hb index（hemoglobin amount）of GHes group were significantly higher than those of placebo group at 6 weeks. Furthermore, GHes group had a tendency to decrease Δb＊（yellowish）at 12 weeks. GHes group showed a significant negative correlation between Δa＊ and Δb＊, but placebo group failed to have this correlation. In the visual evaluation by a dermatologist, GHes group showed a trend toward an improvement in texture and irritation of facial skin at 6 weeks. In addition, erythema and itching were significantly improved at 12 weeks in GHes group compared to placebo group. Conclusions These results indicate that GHes maintains the healthy redness of face and decreases the yellowness of facial skin, leading to the improvement of skin dullness. Moreover, GHes also contributes to the alleviation of sensitive skin. These effects are possibly caused by increasing blood circulation.