薬理と治療

Abstract

Objectives The effect of carbonated beverage containing resistant maltodextrin on the postprandial elevation of blood glucose level was evaluated by a randomized, double-blind, cross-over study. Methods A randomized, double-blinded, crossover trial was performed. The subjects were 50 healthy volunteers whose fasting blood glucose levels are from 110 mg╱dL to 125 mg╱dL or whose blood glucose levels after 2 hours by OGTT are from 140 mg╱dL to 199 mg╱dL. They were randomly divided into two groups and ingested the test beverage containing 5 g（as fiber） of resistant maltodextrin or the placebo beverage with the test meal. Blood glucose levels and blood insulin levels were measured before and 30, 60, 90, 120 minutes after ingestion. Results In comparison with the placebo beverage, the test beverage significantly lowered the postprandial blood glucose levels at 30 minutes（test beverage：152.2±26.8 mg╱dL, placebo beverage：155.9±22.9 mg╱dL, P＜0.05）and at 60 minutes（test beverage：169.1 ±44.3 mg╱dL, placebo beverage：174.1±44.8 mg╱dL, P＜0.05）. Conclusions The data obtained through the trial indicated that the carbonated beverage containing resistant maltodextrin suppresses the elevation of the postprandial blood glucose levels.