薬理と治療

Abstract

Objective The aim of this study was to evaluate the effectiveness of indigestible dextrin-containing tea beverage on the postprandial increase in serum triglyceride level in subjects with moderately high fasting serum triglyceride levels. Methods Volunteers（79 subjects）with their fasting serum triglyceride levels of 120-199 mg╱dL were enrolled in a randomized, placebo-controlled, double-blind, crossover study. Subjects ingested a high-fat meal（44.3 g fat）together with either a test beverage containing 5 g（as dietary fiber）of indigestible dextrin or a placebo beverage without indigestible dextrin. Serum lipids were determined before and 2, 3, 4, and 6 hours after the high-fat meal ingestion. Results When the subjects ingested test beverage, postprandial increases in the levels of serum triglyceride and remnant-like lipoprotein particle cholesterol（RLP-cholesterol）were low compared to those when the subjects ingested placebo beverage. The area under the curve （AUC）for serum triglyceride levels was 1504±478 mg・h╱dL for test beverage and 1593±509 mg・h╱dL for placebo; P＝0.044 and the AUC for serum RLP-cholesterol was 83.8±26.8 mg・h╱dL for test beverage and 89.6±29.5 mg・h╱dL for placebo; P＝0.038. Conclusions The ingestion of indigestible dextrin-containing tea beverage suppresses the increase in the postprandial serum triglyceride and remnant︱like lipoprotein particle cholesterol levels in subjects with moderately high fasting serum triglyceride levels.