薬理と治療

Abstract

Objective The purpose of this study was to elucidate the effects of supplementation of docosahexaenoicacid（DHA）, eicosapentaenoic acid（EPA）and sesame lignans on the serum triglyceride（TG）level, with additional adjusted DHA and EPA intake corresponding to the averagelevel of seafood consumption in the Japanese population.Methods We performed a randomized, double︱blind, placebo-controlled trial. Two hundredhealthy Japanese participants（≥30 years old; TG level, 120︱199 mg╱dL; total intake of DHAand EPA from daily food consumption, ＜500 mg╱day）were randomly divided into test andplacebo groups. Test or placebo samples were administered daily to each group in addition totheir regular diet for 4 weeks. Test samples included 4 capsules（DHA 300 mg, EPA 100 mg,sesame lignans 10 mg［sesamin：episesamin＝1：1］）in combination with seafood substitutefoods（DHA and EPA 450 mg）. Serum TG and remnant︱like particle cholesterol（RLP︱Cho）levels were measured before and after supplementation in both groups.Results The serum TG level was significantly reduced only in the test group, and no decrease was observed in the placebo group. The decrease in the RLP-Cho level was also significantly larger in the test group. No adverse events attributed to the test samples were found in this study. Conclusions The present results indicate that supplementation of DHA, EPA and sesame lignans, in combination with additional adjusted DHA and EPA intake corresponding to the average level of seafood consumption in the Japanese population, decreases serum TG and RLP-Cho levels.