薬理と治療

Abstract

Objectives We developed a black tea polyphenols（BTP）-enriched black tea beverage. A randomized, double-blinded cross-over study was carried out to investigate whether the BTP-enriched black tea beverage would suppress the postprandial elevation of the serum triglyceride level and the serum remnant like particle（RLP）-cholesterol levels for the healthy subjects （serum triglyceride 120︱199 mg╱dL）. Methods Sixty healthy volunteers（serum triglyceride 100-250 mg╱dL）ingested the test drinks（the BTP-enriched black tea beverage or placebo）with the fat︱rich meal（fat 40.0 g）. Blood samples were collected before and 1, 2, 3, 4 and 6 hours after the ingestion, and serum triglyceride levels and serum RLP-cholesterol levels were measured. Further, we selected the data of subjects（serum triglyceride 120-199 mg╱dL）as an additional analysis. Results The BTP-enriched black tea beverage concurrently ingested with the fat-rich meal significantly suppressed the postprandial elevation of the serum triglyceride level at 2 and 3 hours as compared with those observed after concurrent ingestion of placebo and the fat-rich meal （P＜0.05）. The beverage also significantly suppressed the postprandial elevation of serum RLP-cholesterol at 1, 4 and 6 hours（P＜0.05）. Conclusions These results suggested that intake of the BTP-enriched black tea beverage suppresses postprandial elevation of the serum triglyceride levels and the serum RLP-cholesterol levels for healthy subjects（serum triglyceride 120-199 mg╱dL）.