薬理と治療

Abstract

Objectives To evaluate the safety of long-term intake or excessive intake of the carbonated beverage containing resistant maltodextrin and matured hop extract （matured hop bitter acids）. Trial design Randomized double-blinded placebo-controlling parallel-group comparison study. Methods For the safety evaluation of long-term intake or excessive intake of the carbonated beverage, double-blinded parallel group studies were performed respectively. Sixty volunteers were randomly divided into two groups for each study, and took daily 1 bottle（350 mL）of the carbonated beverage that either did or did not contain resistant maltodextrin and matured hop extract for 12 weeks（long-term intake）or 3 bottles of each beverage daily for 4 weeks（excessive intake）. Results In the long-term or excessive intake trials, no abnormal changes triggered by ingestion of the test beverage were observed in clinical findings such as laboratory blood test, urinalysis and physical examination. Conclusion These results indicated that the carbonated beverage containing resistant maltodextrin and matured hop extract were safe for long-term and excessive intake.