薬理と治療

Abstract

Objective The study aimed to verify that ingestion of 3.57 mg astaxanthin- containing capsule for 4 weeks would examine the safety and effects on skin condition. Methods A randomized, double-blind, parallel-group, placebo-controlled study was conducted for 15 male healthy subjects aged 30 to 65 with high oxidative stress levels. The skin moistureand skin condition with the skin image analyzer were measured. Results Intake of the 3.57 mg astaxanthin-containing capsules were significant increase skin moisture（P＝0.0010）, skin color uniformity（P＝0.010）. In addition, safety of astaxanthin-containing capsules were confirmed because side effects, adverse events and remarkable changes in laboratory values were not reported during the test period. Conclusions These results suggest the supplemental intake of astaxanthin improves skin moisture and skin color in high oxidative stress subjects.